Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …

Integrins are key regulators of communication between cells and with their
microenvironment. Eight members of the integrin superfamily recognize the tripeptide motif …

Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

Imaging is a key technology in the early detection of cancers, including X-ray
mammography, low-dose CT for lung cancer, or optical imaging for skin, esophageal, or …

The term “click chemistry” describes a class of organic transformations that were developed
to make chemical synthesis simpler and easier, in essence allowing chemists to combine …

Purpose To develop a new probe for the αvβ6-integrin and assess its potential for PET
imaging of carcinomas. Methods Ga-68-Trivehexin was synthesized by trimerization of the …

Integrins are heterodimeric transmembrane proteins able to connect cells with the micro‐
environment. They represent a family of receptors involved in almost all the hallmarks of …

Many synthetic peptides have been developed for diagnosis and therapy of human cancers
based on their ability to target specific receptors on cancer cell surface or to penetrate the …

Background In the context of nuclear medicine and theranostics, integrin-related research
and development was, for most of the time, focused predominantly on'RGD peptides' and the …

The lack of biomarkers for early diagnosis, clinical stratification and to monitor treatment
response has hampered the development of new therapies for amyotrophic lateral sclerosis …