Connecting copper and cancer: from transition metal signalling to metalloplasia

EJ Ge, AI Bush, A Casini, PA Cobine, JR Cross… - Nature Reviews …, 2022 - nature.com
Copper is an essential nutrient whose redox properties make it both beneficial and toxic to
the cell. Recent progress in studying transition metal signalling has forged new links …

[HTML][HTML] Modulation of intracellular copper levels as the mechanism of action of anticancer copper complexes: Clinical relevance

MV Babak, D Ahn - Biomedicines, 2021 - mdpi.com
Copper (Cu) is a vital element required for cellular growth and development; however, even
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …

Enhancing both biodegradability and efficacy of semiconducting polymer nanoparticles for photoacoustic imaging and photothermal therapy

Y Lyu, J Zeng, Y Jiang, X Zhen, T Wang, S Qiu, X Lou… - ACS …, 2018 - ACS Publications
Theranostic nanoagents are promising for precision medicine. However, biodegradable
nanoagents with the ability for photoacoustic (PA) imaging guided photothermal therapy …

Theranostic approaches in nuclear medicine: current status and future prospects

L Filippi, A Chiaravalloti, O Schillaci… - Expert review of …, 2020 - Taylor & Francis
Introduction: Theranostics is an emerging field in which diagnosis and specific targeted
therapy are combined to achieve a personalized treatment approach to the patient. In …

[HTML][HTML] Implications of physics, chemistry and biology for dosimetry calculations using theranostic pairs

C Miller, J Rousseau, CF Ramogida, A Celler… - Theranostics, 2022 - ncbi.nlm.nih.gov
Theranostics is an emerging paradigm that combines imaging and therapy in order to
personalize patient treatment. In nuclear medicine, this is achieved by using …

A nuclear chocolate box: the periodic table of nuclear medicine

PJ Blower - Dalton Transactions, 2015 - pubs.rsc.org
Radioisotopes of elements from all parts of the periodic table find both clinical and research
applications in radionuclide molecular imaging and therapy (nuclear medicine). This article …

Copper-64: a real theranostic agent

B Gutfilen, SAL Souza, G Valentini - Drug design, development and …, 2018 - Taylor & Francis
Ongoing studies of physiological and pathological processes have led to a corresponding
need for new radiopharmaceuticals, especially when studies are limited by the absence of a …

The emerging role of copper-64 radiopharmaceuticals as cancer theranostics

A Boschi, P Martini, E Janevik-Ivanovska, A Duatti - Drug Discovery Today, 2018 - Elsevier
Highlights•Copper radionuclides for in vivo imaging of biological functions of copper
ions.•Copper-64 has suitable nuclear properties for cancer theranostics.•Radioactive copper …

[HTML][HTML] Hypoxia imaging and theranostic potential of [64Cu][Cu(ATSM)] and ionic Cu(II) salts: a review of current evidence and discussion of the retention …

T Liu, M Karlsen, AM Karlberg, KR Redalen - EJNMMI research, 2020 - Springer
Background Tumor hypoxia (low tissue oxygenation) is an adverse condition of the solid
tumor environment, associated with malignant progression, radiotherapy resistance, and …

[HTML][HTML] Targeting copper in cancer imaging and therapy: a new theragnostic agent

G Capriotti, A Piccardo, E Giovannelli… - Journal of Clinical …, 2022 - mdpi.com
Copper is required for cancer cell proliferation and tumor angiogenesis. Copper-64
radionuclide (64Cu), a form of copper chloride (64CuCl2), is rapidly emerging as a …