Connecting copper and cancer: from transition metal signalling to metalloplasia
Copper is an essential nutrient whose redox properties make it both beneficial and toxic to
the cell. Recent progress in studying transition metal signalling has forged new links …
the cell. Recent progress in studying transition metal signalling has forged new links …
[HTML][HTML] Modulation of intracellular copper levels as the mechanism of action of anticancer copper complexes: Clinical relevance
Copper (Cu) is a vital element required for cellular growth and development; however, even
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …
Enhancing both biodegradability and efficacy of semiconducting polymer nanoparticles for photoacoustic imaging and photothermal therapy
Theranostic nanoagents are promising for precision medicine. However, biodegradable
nanoagents with the ability for photoacoustic (PA) imaging guided photothermal therapy …
nanoagents with the ability for photoacoustic (PA) imaging guided photothermal therapy …
Theranostic approaches in nuclear medicine: current status and future prospects
L Filippi, A Chiaravalloti, O Schillaci… - Expert review of …, 2020 - Taylor & Francis
Introduction: Theranostics is an emerging field in which diagnosis and specific targeted
therapy are combined to achieve a personalized treatment approach to the patient. In …
therapy are combined to achieve a personalized treatment approach to the patient. In …
[HTML][HTML] Implications of physics, chemistry and biology for dosimetry calculations using theranostic pairs
Theranostics is an emerging paradigm that combines imaging and therapy in order to
personalize patient treatment. In nuclear medicine, this is achieved by using …
personalize patient treatment. In nuclear medicine, this is achieved by using …
A nuclear chocolate box: the periodic table of nuclear medicine
PJ Blower - Dalton Transactions, 2015 - pubs.rsc.org
Radioisotopes of elements from all parts of the periodic table find both clinical and research
applications in radionuclide molecular imaging and therapy (nuclear medicine). This article …
applications in radionuclide molecular imaging and therapy (nuclear medicine). This article …
Copper-64: a real theranostic agent
B Gutfilen, SAL Souza, G Valentini - Drug design, development and …, 2018 - Taylor & Francis
Ongoing studies of physiological and pathological processes have led to a corresponding
need for new radiopharmaceuticals, especially when studies are limited by the absence of a …
need for new radiopharmaceuticals, especially when studies are limited by the absence of a …
The emerging role of copper-64 radiopharmaceuticals as cancer theranostics
A Boschi, P Martini, E Janevik-Ivanovska, A Duatti - Drug Discovery Today, 2018 - Elsevier
Highlights•Copper radionuclides for in vivo imaging of biological functions of copper
ions.•Copper-64 has suitable nuclear properties for cancer theranostics.•Radioactive copper …
ions.•Copper-64 has suitable nuclear properties for cancer theranostics.•Radioactive copper …
[HTML][HTML] Hypoxia imaging and theranostic potential of [64Cu][Cu(ATSM)] and ionic Cu(II) salts: a review of current evidence and discussion of the retention …
T Liu, M Karlsen, AM Karlberg, KR Redalen - EJNMMI research, 2020 - Springer
Background Tumor hypoxia (low tissue oxygenation) is an adverse condition of the solid
tumor environment, associated with malignant progression, radiotherapy resistance, and …
tumor environment, associated with malignant progression, radiotherapy resistance, and …
[HTML][HTML] Targeting copper in cancer imaging and therapy: a new theragnostic agent
G Capriotti, A Piccardo, E Giovannelli… - Journal of Clinical …, 2022 - mdpi.com
Copper is required for cancer cell proliferation and tumor angiogenesis. Copper-64
radionuclide (64Cu), a form of copper chloride (64CuCl2), is rapidly emerging as a …
radionuclide (64Cu), a form of copper chloride (64CuCl2), is rapidly emerging as a …