Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have
mapped the activity and functional connectivity of cholinergic neurons have shown that the …

Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are
widely distributed both pre-and post-synaptically in the mammalian brain. By modulating …

Primary prevention trials have shifted their focus to the earliest stages of Alzheimer's disease
(AD). Autopsy data indicates that the neuromodulatory subcortical systems'(NSS) nuclei are …

Nicotinic acetylcholine receptors (nAChRs) are master regulators of immune functions via
the cholinergic anti-inflammatory pathway and are expressed in microglia, the brain's …

The study of nicotinic acetylcholine receptors (nAChRs) has significantly progressed in the
last decade, due to a) the improved techniques available for structural studies; b) the …

Traumatic injury induces sterile inflammation, an immune response often associated with
severe organ dysfunction. The cholinergic system acts as an anti-inflammatory in injured …

Cholinergic receptors represent a promising class of diagnostic and therapeutic targets due
to their significant involvement in cognitive decline associated with neurological disorders …

Multiple lines of evidence argue for lower levels of cortical muscarinic M1 receptors
(CHRM1) in people with schizophrenia which is possibly due to a sub-group within the …

The neuromodulatory subcortical system (NSS) nuclei are critical hubs for survival, hedonic
tone, and homeostasis. Tau‐associated NSS degeneration occurs early in Alzheimer's …