Molecular imaging of innate immunity and immunotherapy

W Xia, N Singh, S Goel, S Shi - Advanced Drug Delivery Reviews, 2023 - Elsevier
The innate immune system plays a key role as the first line of defense in various human
diseases including cancer, cardiovascular and inflammatory diseases. In contrast to tissue …

Prognostic Value of TSPO PET Before Radiotherapy in Newly Diagnosed IDH–Wild-Type Glioblastoma

NL Albert, DV Nelwan, DF Fleischmann… - Journal of Nuclear …, 2023 - Soc Nuclear Med
The 18-kDa translocator protein (TSPO) is gaining recognition as a relevant target in
glioblastoma imaging. However, data on the potential prognostic value of TSPO PET …

Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution

LM Bartos, SV Kirchleitner, ZI Kolabas, S Quach… - Science …, 2023 - science.org
Various cellular sources hamper interpretation of positron emission tomography (PET)
biomarkers in the tumor microenvironment (TME). We developed an approach of …

[HTML][HTML] In vivo quantitative imaging of glioma heterogeneity employing positron emission tomography

C Barca, C Foray, B Zinnhardt, A Winkeler, U Herrlinger… - Cancers, 2022 - mdpi.com
Simple Summary Defining glioma heterogeneity represents a promising strategy to unravel
the mechanisms behind therapy resistance and tumor recurrence. The current review …

[HTML][HTML] 18 kDa translocator protein positron emission tomography facilitates early and robust tumor detection in the immunocompetent SB28 glioblastoma mouse …

LM Bartos, SV Kirchleitner, J Blobner, K Wind… - Frontiers in …, 2022 - frontiersin.org
Introduction: The 18 kDa translocator protein (TSPO) receives growing interest as a
biomarker in glioblastoma. Mouse models can serve as an important tool for the …

[HTML][HTML] Distinguished Functions of Microglia in the Two Stages of Oxygen-Induced Retinopathy: A Novel Target in the Treatment of Ischemic Retinopathy

Z Zhou, Y Jing, Y Niu, T Chang, J Sun, C Guo, Y Wang… - Life, 2022 - mdpi.com
Microglia is the resident immune cell in the retina, playing the role of immune surveillance in
a traditional concept. With the heated focus on the mechanisms of microglia in pathological …

[HTML][HTML] The Traumatic Inoculation Process Affects TSPO Radioligand Uptake in Experimental Orthotopic Glioblastoma

L Gold, E Barci, M Brendel, M Orth, J Cheng… - Biomedicines, 2024 - mdpi.com
Background: The translocator protein (TSPO) has been proven to have great potential as a
target for the positron emission tomography (PET) imaging of glioblastoma. However, there …