Poorly differentiated gastroenteropancreatic neuroendocrine carcinomas are aggressive
neoplasms of challenging clinical management. A small proportion of patients with early …

The aberrant proteolytic landscape of the tumor microenvironment is a key contributor of
cancer progression. Overexpression of urokinase plasminogen activator (uPA) and/or its …

No clinically approved tumor-specific imaging agents for head and neck cancer are currently
available. The identification of biomarkers with a high and homogenous expression in tumor …

Purpose Radical resection is paramount for curative oncological surgery. Fluorescence-
guided surgery (FGS) aids in intraoperative identification of tumor-positive resection …

A comprehensive literature reports on the correlation between elevated levels of urokinase-
type plasminogen activator receptor (uPAR) and the severity of diseases with chronic …

Recent strides in molecular pathology have unveiled distinctive alterations at the molecular
level throughout the onset and progression of diseases. Enhancing the in vivo visualization …

Simple Summary Pancreatic ductal adenocarcinomas (PDACs) with gene amplification or
overexpression of urokinase-type plasminogen activator receptor (uPAR) have a particularly …

Abstract Purpose [64Cu] Cu-DOTA-AE105 urokinase-type plasminogen activator receptor
(uPAR)-PET/CT is a novel and promising imaging modality for cancer visualization, although …

The detection of lymph node metastases is a major challenge in oral and oropharyngeal
squamous cell carcinoma (OSCC and OPSCC). 68Ga-NOTA-AE105 is a novel positron …

Urokinase‑type plasminogen activator receptor (uPAR) serves as the receptor for uPA and
the uPA‑uPAR complex initiates the extracellular matrix degradation cascade. In cancer …