Abstract Cancer-Associated Fibroblasts (CAFs) represent the most prominent component of
the tumor microenvironment (TME). Recent studies demonstrated that CAF are …

Brain metastases are a challenging manifestation of renal cell carcinoma. We have a limited
understanding of brain metastasis tumor and immune biology, drivers of resistance to …

Background Checkpoint inhibition has radically improved the perspective for patients with
metastatic cancer, but predicting who will not respond with high certainty remains difficult …

Nowadays, one of the most effective methods of tumor immunotherapy is blocking
programmed cell death protein 1/programmed cell death protein ligand 1 (PD-1/PD-L1) …

Immunotherapy with checkpoint inhibitors has prompted a major change not only in cancer
treatment but also in medical imaging. In parallel with the implementation of new drugs …

Abstract Purpose PD-L1 PET imaging allows for the whole body measuring its expression
across primary and metastatic tumors and visualizing its spatiotemporal dynamics before …

Early diagnosis is essential for completely eradicating skin cancer and maximizing patients'
clinical benefits. Emerging optical imaging modalities such as reflectance confocal …

Although antibodies are well developed and widely used in cancer therapy and diagnostic
fields, some defects remain, such as poor tissue penetration, long in vivo metabolic …

The advent of immune checkpoint inhibitors has reinvigorated the field of immuno-oncology.
These monoclonal antibody-based therapies allow the immune system to recognize and …

Programmed death-1 is a protein found on the surface of immune cells that can interact with
its ligand, programmed death-ligand 1 (PD-L1), which is expressed on the plasma …