FDA approval summary: lutetium Lu 177 vipivotide tetraxetan for patients with metastatic castration-resistant prostate cancer

J Fallah, S Agrawal, H Gittleman, MH Fiero… - Clinical Cancer …, 2023 - AACR
Abstract On March 23, 2022, the FDA approved Pluvicto (lutetium Lu 177 vipivotide
tetraxetan, also known as 177Lu-PSMA-617) for the treatment of adult patients with prostate …

[HTML][HTML] Learn from antibody–drug conjugates: consideration in the future construction of peptide-drug conjugates for cancer therapy

M Wu, W Huang, N Yang, Y Liu - Experimental Hematology & Oncology, 2022 - Springer
Cancer is one of the leading causes of death worldwide due to high heterogeneity. Although
chemotherapy remains the mainstay of cancer therapy, non-selective toxicity and drug …

Synthesis of Secondary Trifluoromethyl Boronic Esters through Visible Light Induced Decarboxylative Alkylation Reactions

W Li, J Gao, T Mao, X Li, AJ Wang… - Advanced Synthesis …, 2023 - Wiley Online Library
We demonstrated a practical and general methodology for the synthesis of secondary
trifluoromethyl boronic esters through visible light induced decarboxylative alkylation …

[HTML][HTML] A prospective head-to-head comparison of [68Ga]Ga-P16-093 and [68Ga]Ga-PSMA-11 PET/CT in patients with primary prostate cancer

G Wang, L Li, M Zhu, J Zang, J Wang, R Wang… - European Journal of …, 2023 - Springer
Purpose We aimed to compare the diagnostic performance and biodistribution of two similar
PET agents,[68Ga] Ga-P16-093 and [68Ga] Ga-PSMA-11, in the same group of primary …

Bridging the gap between lab and clinic for nanodiagnostics

RM Pallares, F Kiessling, T Lammers - Nanomedicine, 2023 - Future Medicine
Nanodiagnostics have been used in clinical diagnosis for over 60 years [1]. The
nanoparticles tend to be either intrinsically (optically or magnetically) active or labeled with …

Peptide-Drug Conjugates: Design, Chemistry, and Drug Delivery System as a Novel Cancer Theranostic

SFA Rizvi, L Zhang, H Zhang… - ACS Pharmacology & …, 2024 - ACS Publications
The emergence of peptide–drug conjugates (PDCs) that utilize target-oriented peptide
moieties as carriers of cytotoxic payloads, interconnected with various cleavable …

From concept to regulatory drug approval: lessons for theranostics

M Perera, MJ Morris - Journal of Nuclear Medicine, 2022 - Soc Nuclear Med
Radiopharmaceutical therapy is an emerging treatment modality that has demonstrated
increasing importance as a significant component in the treatment of cancer. Prostate cancer …

Cancer theranostics: recent global advances

R Jahani, M Mosayebnia, SM Mortazavi… - … for Cancer Research, 2024 - Elsevier
The incidence of cancer and its subsequent morbidity and mortality are increasing
dramatically all over the world. Early diagnosis and treatment of cancer substantially …

Diagnostic test evaluation

SJ Wang - Translational Radiation Oncology, 2023 - Elsevier
A diagnostic test can be a clinical laboratory test in a broad term, a medical imaging device,
or a medical imaging drug. Medical imaging drugs are drugs and biological products …