FAPI PET: fibroblast activation protein inhibitor use in oncologic and nononcologic disease
Y Mori, K Dendl, J Cardinale, C Kratochwil, FL Giesel… - Radiology, 2023 - pubs.rsna.org
Gallium 68 (68Ga)–labeled fibroblast activation protein (FAP) inhibitor (FAPI) PET is based
on the molecular targeting of the FAP, which is known to be highly expressed in the major …
on the molecular targeting of the FAP, which is known to be highly expressed in the major …
[HTML][HTML] Fibroblast activation protein-based theranostics in cancer research: a state-of-the-art review
In recent years, quinoline-based fibroblast activation protein (FAP) inhibitors (FAPI) have
shown promising results in the diagnosis of cancer and several other diseases, making them …
shown promising results in the diagnosis of cancer and several other diseases, making them …
[HTML][HTML] Preclinical evaluation of FAP-2286 for fibroblast activation protein targeted radionuclide imaging and therapy
D Zboralski, A Hoehne, A Bredenbeck… - European journal of …, 2022 - Springer
Purpose Fibroblast activation protein (FAP) is a membrane-bound protease that has limited
expression in normal adult tissues but is highly expressed in the tumor microenvironment of …
expression in normal adult tissues but is highly expressed in the tumor microenvironment of …
[HTML][HTML] Fibroblast activation protein-α as a target in the bench-to-bedside diagnosis and treatment of tumors: a narrative review
L Xin, J Gao, Z Zheng, Y Chen, S Lv, Z Zhao… - Frontiers in …, 2021 - frontiersin.org
Fibroblast activation protein-α (FAP) is a type II integral serine protease that is specifically
expressed by activated fibroblasts. Cancer-associated fibroblasts (CAFs) in the tumor stroma …
expressed by activated fibroblasts. Cancer-associated fibroblasts (CAFs) in the tumor stroma …
[HTML][HTML] FAP and FAPI-PET/CT in malignant and non-malignant diseases: a perfect symbiosis?
K Dendl, SA Koerber, C Kratochwil, J Cardinale… - Cancers, 2021 - mdpi.com
Simple Summary FAPI represents a novel class of radiotracers demonstrating promising
results in terms of a high uptake in concordance with low background noise in several …
results in terms of a high uptake in concordance with low background noise in several …
Clinical summary of fibroblast activation protein inhibitor-based radiopharmaceuticals: cancer and beyond
Fibroblast activation protein (FAP) is a type II membrane-bound glycoprotein which is
overexpressed in cancer-associated fibroblasts and activated fibroblasts at wound …
overexpressed in cancer-associated fibroblasts and activated fibroblasts at wound …
[68Ga]Ga-DOTA-FAPI-04 PET/CT in the evaluation of gastric cancer: comparison with [18F]FDG PET/CT
R Lin, Z Lin, Z Chen, S Zheng, J Zhang, J Zang… - European Journal of …, 2022 - Springer
Purpose This study aimed to compare the performance of [68Ga] Ga-DOTA-FAPI-04 and
[18F] FDG PET/CT in the evaluation of primary and metastatic lesions of gastric cancer …
[18F] FDG PET/CT in the evaluation of primary and metastatic lesions of gastric cancer …
Comparison of [68Ga]Ga-FAPI and [18F]FDG uptake in patients with gastric signet-ring-cell carcinoma: a multicenter retrospective study
Objective In this study, we investigated the role of [68Ga] Ga-FAPI PET imaging in the
detection of primary and metastatic gastric signet-ring-cell carcinoma (GSRCC) and …
detection of primary and metastatic gastric signet-ring-cell carcinoma (GSRCC) and …
Comparison of the diagnostic efficacy of 68 Ga-FAPI-04 PET/MR and 18F-FDG PET/CT in patients with pancreatic cancer
Purpose We sought to assess the performance of 68 Ga-FAPI-04 PET/MR for the diagnosis
of primary tumours as well as metastatic lesions in patients with pancreatic cancer and to …
of primary tumours as well as metastatic lesions in patients with pancreatic cancer and to …
[HTML][HTML] Role of serine proteases at the tumor-stroma interface
R Tagirasa, E Yoo - Frontiers in immunology, 2022 - frontiersin.org
During tumor development, invasion and metastasis, the intimate interaction between tumor
and stroma shapes the tumor microenvironment and dictates the fate of tumor cells. Stromal …
and stroma shapes the tumor microenvironment and dictates the fate of tumor cells. Stromal …