Imaging-guided targeted radionuclide tumor therapy: From concept to clinical translation

J Sun, Z Huangfu, J Yang, G Wang, K Hu, M Gao… - Advanced Drug Delivery …, 2022 - Elsevier
Since the first introduction of sodium iodide I-131 for use with thyroid patients almost 80
years ago, more than 50 radiopharmaceuticals have reached the markets for a wide range …

[HTML][HTML] Personalized dosimetry in targeted radiation therapy: a look to methods, tools and critical aspects

R Danieli, A Milano, S Gallo, I Veronese… - Journal of Personalized …, 2022 - mdpi.com
Targeted radiation therapy (TRT) is a strategy increasingly adopted for the treatment of
different types of cancer. The urge for optimization, as stated by the European Council …

[PDF][PDF] Normal-tissue tolerance to radiopharmaceutical therapies, the knowns and the unknowns

RL Wahl, G Sgouros, A Iravani, H Jacene… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Radiopharmaceutical therapies are gaining increasing prominence as they improve survival
in patients with common diseases such as metastatic prostate cancer (1, 2). However …

18F-FDOPA PET for the noninvasive prediction of glioma molecular parameters: a radiomics study

T Zaragori, J Oster, V Roch, G Hossu… - Journal of Nuclear …, 2022 - Soc Nuclear Med
The assessment of gliomas by 18F-FDOPA PET imaging as an adjunct to MRI showed high
performance by combining static and dynamic features to noninvasively predict the isocitrate …

[HTML][HTML] The relationship between tumour dosimetry, response, and overall survival in patients with unresectable Neuroendocrine Neoplasms (NEN) treated with 177 …

R Alipour, P Jackson, M Bressel, A Hogg… - European Journal of …, 2023 - Springer
Abstract Peptide Receptor Radionuclide Therapy (PRRT) delivers targeted radiation to
Somatostatin Receptor (SSR) expressing Neuroendocrine Neoplasms (NEN). We sought to …

[HTML][HTML] Understanding the Radiobiological Mechanisms Induced by 177Lu-DOTATATE in Comparison to External Beam Radiation Therapy

W Delbart, J Karabet, G Marin, S Penninckx… - International journal of …, 2022 - mdpi.com
Radionuclide Therapy (RNT) with 177Lu-DOTATATE targeting somatostatin receptors
(SSTRs) in neuroendocrine tumours (NET) has been successfully used in routine clinical …

[HTML][HTML] Toxicity Assessment of [177Lu]Lu−iFAP/iPSMA Nanoparticles Prepared under GMP-Compliant Radiopharmaceutical Processes

T Hernández-Jiménez, P Cruz-Nova, A Ancira-Cortez… - Nanomaterials, 2022 - mdpi.com
The fibroblast activation protein (FAP) is heavily expressed in fibroblasts associated with the
tumor microenvironment, while the prostate-specific membrane antigen (PSMA) is …

[HTML][HTML] Developments in combining targeted radionuclide therapies and immunotherapies for cancer treatment

CP Kerr, JJ Grudzinski, TP Nguyen, R Hernandez… - Pharmaceutics, 2022 - mdpi.com
Targeted radionuclide therapy (TRT) and immunotherapy are rapidly growing classes of
cancer treatments. Basic, translational, and clinical research are now investigating …

A radiomic‐ and dosiomic‐based machine learning regression model for pretreatment planning in 177Lu‐DOTATATE therapy

D Plachouris, V Eleftheriadis, T Nanos… - Medical …, 2023 - Wiley Online Library
Background Standardized patient‐specific pretreatment dosimetry planning is mandatory in
the modern era of nuclear molecular radiotherapy, which may eventually lead to …

SPECT at the speed of PET: a feasibility study of CZT-based whole-body SPECT/CT in the post 177Lu-DOTATATE and 177Lu-PSMA617 setting

H Song, V Ferri, H Duan, CM Aparici… - European Journal of …, 2023 - Springer
Purpose To evaluate the feasibility of using the StarGuide (General Electric Healthcare,
Haifa, Israel), a new generation multi-detector cadmium-zinc-telluride (CZT)-based …