Astatine-211 (211At) has physical properties that make it one of the top candidates for use
as a radiation source for alpha particle-based radionuclide therapy, also referred as targeted …

Targeted radionuclide therapy has become increasingly prominent as a nuclear medicine
subspecialty. For many decades, treatment with radionuclides has been mainly restricted to …

Pretargeted radioimmunodiagnosis and radioimmunotherapy aim to efficiently combine
antitumor antibodies and medicinal radioisotopes for high-contrast imaging and high …

Due to its simplicity, high efficiency, and chemo-selectivity, bioorthogonal chemistry has
shown a great application potential in pre-targeting. Currently, four bioorthogonal pairs as …

The present article highlights the important progress made in the last two decades in the
fields of molecular imaging and radionuclide therapy. Advancements in radiometal-based …

Microbubbles are 1–10 μm diameter gas-filled acoustically-active particles, typically
stabilized by a phospholipid monolayer shell. Microbubbles can be engineered through …

Pretargeting is a technique that uses macromolecules as targeting agents for nuclear
imaging and therapy with the goal of reducing the radiation toxicity to healthy tissues often …

Radioimmunotherapy (RIT) is a cancer treatment that combines radiation therapy with tumor-
directed monoclonal antibodies (Abs). Although RIT had been introduced for the treatment of …

To enhance targeting efficacy in the radioimmunotherapy of disseminated cancer, several
pretargeting strategies have been developed. In pretargeted radioimmunotherapy, the tumor …

The goal of reducing the total-body radiation dose of macromolecule-based nuclear
medicine with a 2-step pretargeting strategy has been achieved with several pretargeting …