Advances in aptamer-based nuclear imaging

W Song, Y Song, Q Li, C Fan, X Lan, D Jiang - European Journal of …, 2022 - Springer
Aptamers are short oligonucleotides that bind to specific target molecules. They have been
extensively explored in biomedical applications, including biosensing, medical imaging, and …

Clinical pharmacology of radiotheranostics in oncology

ET Te Beek, J Burggraaf… - Clinical …, 2023 - Wiley Online Library
The combined use of diagnostic and therapeutic radioligands with the same molecular
target, also known as theranostics, enables accurate patient selection, targeted therapy, and …

Development of fibroblast activation protein inhibitor-based dimeric radiotracers with improved tumor retention and antitumor efficacy

L Zhao, J Chen, Y Pang, J Fang, K Fu… - Molecular …, 2022 - ACS Publications
Fibroblast activation protein (FAP), a fundamental component of the tumor stroma, is
overexpressed in cancer-associated fibroblasts (CAFs). As a promising theranostic probe …

Defining triple‐negative breast cancer with neuroendocrine differentiation (TNBC‐NED)

SM Hacking, E Yakirevich… - The Journal of Pathology …, 2023 - Wiley Online Library
Primary breast neuroendocrine (NE) neoplasms are uncommon, and definitions harbor
controversy. We retrospectively collected 73 triple‐negative breast cancers (TNBC) and …

[HTML][HTML] Peptide receptor radionuclide therapy targeting the somatostatin receptor: basic principles, clinical applications and optimization strategies

N Ahmadi Bidakhvidi, K Goffin, J Dekervel, K Baete… - Cancers, 2021 - mdpi.com
Simple Summary Peptide receptor radionuclide therapy (PRRT) is a systemic treatment
consisting of the administration of a tumor-targeting radiopharmaceutical into the circulation …

[HTML][HTML] Safety and efficacy of peptide receptor radionuclide therapy with 177Lu-DOTA-EB-TATE in patients with metastatic neuroendocrine tumors

Y Jiang, Q Liu, G Wang, H Sui, R Wang, J Wang… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: This study aimed to assess the safety, efficacy, and survival of 177 Lu-DOTA-EB-
TATE in patients with metastatic neuroendocrine tumors (NETs). Methods: Thirty patients …

[HTML][HTML] Current status and future perspective of radiopharmaceuticals in China

J Hu, H Li, Y Sui, J Du - European Journal of Nuclear Medicine and …, 2022 - Springer
Radiopharmaceuticals are essential components of nuclear medicine and serve as one of
the cornerstones of molecular imaging and precision medicine. They provide new means …

[HTML][HTML] Strategies towards improving clinical outcomes of peptide receptor radionuclide therapy

NS Minczeles, J Hofland, WW de Herder… - Current Oncology …, 2021 - Springer
Abstract Purpose of Review Peptide receptor radionuclide therapy (PRRT) with [177 Lu-
DOTA 0, Tyr 3] octreotate is an effective and safe second-or third-line treatment option for …

[HTML][HTML] Peptide receptor radionuclide therapy combinations for neuroendocrine tumours in ongoing clinical trials: status 2023

G di Santo, G Santo, A Sviridenko, I Virgolini - Theranostics, 2024 - ncbi.nlm.nih.gov
A growing body of literature reports on the combined use of peptide receptor radionuclide
therapy (PRRT) with other anti-tumuor therapies in order to anticipate synergistic effects with …

[HTML][HTML] Palmitic Acid-Conjugated Radiopharmaceutical for Integrin αvβ3-Targeted Radionuclide Therapy

G Yang, H Gao, C Luo, X Zhao, Q Luo, J Shi, F Wang - Pharmaceutics, 2022 - mdpi.com
Peptide receptor radionuclide therapy (PRRT) is an emerging approach for patients with
unresectable or metastatic tumors. Our previously optimized RGD peptide (3PRGD2) has …