[HTML][HTML] Translational molecular imaging and drug development in Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects
elderly people and constitutes a major source of disability worldwide. Notably, the …
elderly people and constitutes a major source of disability worldwide. Notably, the …
Restoration of metal homeostasis: A potential strategy against neurodegenerative diseases
YY Zhang, XS Li, KD Ren, J Peng, XJ Luo - Ageing Research Reviews, 2023 - Elsevier
Metal homeostasis is critical to normal neurophysiological activity. Metal ions are involved in
the development, metabolism, redox and neurotransmitter transmission of the central …
the development, metabolism, redox and neurotransmitter transmission of the central …
[HTML][HTML] A review of molecular imaging of glutamate receptors
JH Kim, J Marton, SM Ametamey, P Cumming - Molecules, 2020 - mdpi.com
Molecular imaging with positron emission tomography (PET) and single photon emission
computed tomography (SPECT) is a well-established and important in vivo technique to …
computed tomography (SPECT) is a well-established and important in vivo technique to …
Low-level brain somatic mutations are implicated in schizophrenia
Background Somatic mutations arising from the brain have recently emerged as significant
contributors to neurodevelopmental disorders, including childhood intractable epilepsy and …
contributors to neurodevelopmental disorders, including childhood intractable epilepsy and …
A novel NMDA receptor test model based on hiPSC-derived neural cells
P Disse, I Aymanns, N Ritter, S Peischard… - Biological …, 2023 - degruyter.com
N-Methyl-D-aspartate receptors (NMDARs) are central for learning and information
processing in the brain. Dysfunction of NMDARs can play a key role in the pathogenesis of …
processing in the brain. Dysfunction of NMDARs can play a key role in the pathogenesis of …
Evaluation of (rac)-,(R)-, and (S)-18F-OF-NB1 for Imaging GluN2B subunit–containing N-Methyl-d-Aspartate receptors in nonhuman primates
Despite 2 decades of research, no N-methyl-d-aspartate (NMDA) glutamate receptor (GluN)
subtype 2B (GluN1/2B) radioligand is yet clinically validated. Previously, we reported on …
subtype 2B (GluN1/2B) radioligand is yet clinically validated. Previously, we reported on …
First-in-humans brain PET imaging of the GluN2B-containing N-methyl-d-aspartate receptor with (R)-11C-Me-NB1
The N-methyl-d-aspartate receptor (NMDAR) plays a crucial role in neurodegenerative
diseases such as Alzheimer disease and in the treatment of major depression by fast-acting …
diseases such as Alzheimer disease and in the treatment of major depression by fast-acting …
[HTML][HTML] Pharmacological potential of 3-benzazepines in NMDAR-linked pathophysiological processes
N Ritter, P Disse, B Wünsch, G Seebohm… - Biomedicines, 2023 - mdpi.com
The number of N-Methyl-d-aspartate receptor (NMDAR) linked neurodegenerative diseases
such as Alzheimer's disease and dementia is constantly increasing. This is partly due to …
such as Alzheimer's disease and dementia is constantly increasing. This is partly due to …
Comparison of three novel radiotracers for GluN2B-containing NMDA receptors in non-human primates: (R)-[11C]NR2B-Me, (R)-[18F]of-Me-NB1, and (S)-[18F]of …
The NMDA receptor GluN2B subunit is a target of interest in neuropsychiatric disorders but
to date there is no selective radiotracer available to quantify its availability in vivo. Here we …
to date there is no selective radiotracer available to quantify its availability in vivo. Here we …
[HTML][HTML] Development and Validation of [3H]OF-NB1 for Preclinical Assessment of GluN1/2B Candidate Drugs
GluN2B-enriched N-methyl-d-aspartate receptors (NMDARs) are implicated in several
neurodegenerative and psychiatric diseases, such as Alzheimer's disease. No clinically …
neurodegenerative and psychiatric diseases, such as Alzheimer's disease. No clinically …