Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two interrelated
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …

The impact of inflammation on the outcome of many medical conditions such as
cardiovascular diseases, neurological disorders, infections, cancer, and autoimmune …

Background: Macrophages, innate immune cells that reside in all organs, defend the host
against infection and injury. In the heart and vasculature, inflammatory macrophages also …

BACKGROUND: Immune checkpoint inhibitors (ICIs), antibodies targeting PD-1
(programmed cell death protein 1)/PD-L1 (programmed death-ligand 1) or CTLA4 (cytotoxic …

The innate immune system plays a key role as the first line of defense in various human
diseases including cancer, cardiovascular and inflammatory diseases. In contrast to tissue …

Among the diverse populations of myeloid cells that reside within the healthy and diseased
heart, CC chemokine receptor type 2 (CCR2) is specifically expressed on inflammatory …

Real-time monitoring of post-transplant immune response is critical to prolong the survival of
grafts. The current gold standard for assessing the immune response to graft is biopsy …

Growing evidence implicates the immune system as a critical mediator of cardiovascular
disease progression and a viable therapeutic target. Increased inflammatory cell activity is …

Chemokine receptors are important components of cellular signaling and play a critical role
in directing leukocytes during inflammatory reactions. Their importance extends to numerous …

In the past 2 decades, research on atherosclerotic cardiovascular disease has uncovered
inflammation to be a key driver of the pathophysiological process. A pressing need therefore …