Since their discovery as distinct receptor proteins, the specific physiopathological role of
sigma receptors (σRs) has been deeply investigated. It has been reported that these …

The sigma-2 receptor was originally defined pharmacologically and recently identified as
TMEM97. TMEM97 has been validated as a biomarker of proliferative status and the …

The sigma receptors were classified into sigma-1 and sigma-2 receptor based on their
different pharmacological profiles. In the past two decades, our understanding of the …

Introduction: Cancer is a dreadful disorder that is emerging as one of the leading causes of
mortality across the globe. The complex tumor environment, supplemented with drawbacks …

Novel ligands with the 6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinoline or 5, 6-
dimethoxyisoindoline pharmacophore were designed and synthesized for evaluation of their …

Breast cancer is one of the most common malignancies in women, with high morbidity and
mortality rates. In breast cancer, the use of novel radiopharmaceuticals in nuclear medicine …

The goals of precision oncology are to provide targeted drug therapy based on each
individual's specific tumor biology, and to enable the prediction and early assessment of …

The management of advanced-stage melanoma is clinically challenging, mainly because of
its resistance to the currently available therapies. Therefore, it is important to develop …

Purpose This study evaluated the ability of 18 F-Fluorodeoxyglucose (FDG) and 18 F-
Fluorothymidine (FLT) imaging with positron emission tomography (PET) to measure early …

Sigma-2 receptor plays key roles in promoting tumor cell apoptosis, enhancing efficacy of
anti-tumor drugs, blocking signal transduction controlled by Aβ oligomers, regulating Ca2+ …