ImmunoPET: concept, design, and applications

W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

[HTML][HTML] Nano carrier drug delivery systems for the treatment of neuropsychiatric disorders: Advantages and limitations

Y Zorkina, O Abramova, V Ushakova, A Morozova… - Molecules, 2020 - mdpi.com
Neuropsychiatric diseases are one of the main causes of disability, affecting millions of
people. Various drugs are used for its treatment, although no effective therapy has been …

Hyperosmolar blood–brain barrier opening using intra-arterial injection of hyperosmotic mannitol in mice under real-time MRI guidance

C Chu, A Jablonska, Y Gao, X Lan, WG Lesniak… - Nature protocols, 2022 - nature.com
The blood–brain barrier (BBB) is the main obstacle to the effective delivery of therapeutic
agents to the brain, compromising treatment efficacy for a variety of neurological disorders …

Dendrimer as a momentous tool in tissue engineering and regenerative medicine

A Shaikh, P Kesharwani, V Gajbhiye - Journal of Controlled Release, 2022 - Elsevier
Dendrimers have been comprehensively used for cargo delivery, nucleic acid delivery
(genes, miRNA/siRNAs), delivery of macromolecules, and other various biomedical …

Advances in drug delivery technology for the treatment of glioblastoma multiforme

GD Cha, T Kang, S Baik, D Kim, SH Choi… - Journal of controlled …, 2020 - Elsevier
Glioblastoma multiforme (GBM) is a particularly aggressive and malignant type of brain
tumor, notorious for its high recurrence rate and low survival rate. The treatment of GBM is …

[HTML][HTML] Multimodal molecular imaging in drug discovery and development

I Vermeulen, EM Isin, P Barton, B Cillero-Pastor… - Drug discovery today, 2022 - Elsevier
In addition to individual imaging techniques, the combination and integration of several
imaging techniques, so-called multimodal imaging, can provide large amounts of …

Current approaches to facilitate improved drug delivery to the central nervous system

M Markowicz-Piasecka, P Darłak, A Markiewicz… - European Journal of …, 2022 - Elsevier
Although many pharmaceuticals have therapeutic potentials for central nervous system
(CNS) diseases, few of these agents have been effectively administered. It is due to the fact …

The role of 89Zr-immuno-PET in navigating and derisking the development of biopharmaceuticals

GAMS van Dongen, W Beaino… - Journal of Nuclear …, 2021 - Soc Nuclear Med
The identification of molecular drivers of disease and the compelling rise of biotherapeutics
have impacted clinical care but have also come with challenges. Such therapeutics include …

[HTML][HTML] ImmunoPET: antibody-based PET imaging in solid tumors

R Manafi-Farid, B Ataeinia, S Ranjbar… - Frontiers in …, 2022 - frontiersin.org
Immuno-positron emission tomography (immunoPET) is a molecular imaging modality
combining the high sensitivity of PET with the specific targeting ability of monoclonal …

[HTML][HTML] Brain delivery of single-domain antibodies: A focus on VHH and VNAR

E Pothin, D Lesuisse, P Lafaye - Pharmaceutics, 2020 - mdpi.com
Passive immunotherapy, ie, treatment with therapeutic antibodies, has been increasingly
used over the last decade in several diseases such as cancers or inflammation. However …