ImmunoPET: concept, design, and applications

W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles

DM Griffith, H Li, MV Werrett, PC Andrews… - Chemical Society …, 2021 - pubs.rsc.org
Bismuth as a relatively non-toxic and inexpensive metal with exceptional properties has
numerous biomedical applications. Bismuth-based compounds are used extensively as …

[HTML][HTML] Radiochemistry for positron emission tomography

J Rong, A Haider, TE Jeppesen, L Josephson… - Nature …, 2023 - nature.com
Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …

Photochemical reactions in the synthesis of protein–drug conjugates

JP Holland, M Gut, S Klingler, R Fay… - … –A European Journal, 2020 - Wiley Online Library
The ability to modify biologically active molecules such as antibodies with drug molecules,
fluorophores or radionuclides is crucial in drug discovery and target identification. Classic …

Charting the Chemical and Mechanistic Scope of Light-Triggered Protein Ligation

DF Earley, A Guillou, S Klingler, R Fay, M Gut… - JACS Au, 2022 - ACS Publications
The creation of discrete, covalent bonds between a protein and a functional molecule like a
drug, fluorophore, or radiolabeled complex is essential for making state-of-the-art tools that …

[HTML][HTML] Natural product-based radiopharmaceuticals: Focus on curcumin and its analogs, flavonoids, and marine peptides

H Wongso - Journal of Pharmaceutical Analysis, 2022 - Elsevier
Natural products provide a bountiful supply of pharmacologically relevant precursors for the
development of various drug-related molecules, including radiopharmaceuticals. However …

[HTML][HTML] Prostate-specific membrane antigen (PSMA) theranostics for treatment of oligometastatic prostate cancer

KA Plichta, SA Graves, JM Buatti - International journal of molecular …, 2021 - mdpi.com
Theranostics, a combination of therapy and diagnostics, is a field of personalized medicine
involving the use of the same or similar radiopharmaceutical agents for the diagnosis and …

[HTML][HTML] In vivo cell tracking using PET: Opportunities and challenges for clinical translation in oncology

LM Lechermann, D Lau, B Attili, L Aloj, FA Gallagher - Cancers, 2021 - mdpi.com
Simple Summary Tracking therapeutic cells with non-invasive imaging methods has the
potential to provide important information on the efficacy of cell therapies. In oncology, for …

Light-induced synthesis of protein conjugates and its application in photoradiosynthesis of 89Zr-radiolabeled monoclonal antibodies

A Guillou, DF Earley, M Patra, JP Holland - Nature protocols, 2020 - nature.com
Efficient methods to functionalize proteins are essential for the development of many
diagnostic and therapeutic compounds, such as fluorescent probes for …

ImmunoPET imaging of hematological malignancies: From preclinical promise to clinical reality

Y Dun, G Huang, J Liu, W Wei - Drug Discovery Today, 2022 - Elsevier
Immuno-positron emission tomography (immunoPET) imaging is a paradigm-shifting
imaging technique for whole-body and all-lesion tumor detection, based on the combined …