Neuroinflammation is initiated when glial cells, mainly microglia, are activated by threats to
the neural environment, such as pathogen infiltration or neuronal injury. Although …

Abstract Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …

Triggering receptor expressed on myeloid cells 2 (TREM 2) is essential for the transition of
homeostatic microglia to a disease‐associated microglial state. To enhance TREM 2 activity …

TREM2 is an Alzheimer's disease (AD) risk gene expressed in microglia. To study the role of
Trem2 in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus …

Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's
disease (AD). Both cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2), a …

In the last decade, positron emission tomography (PET) and single-photon emission
computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the …

Neuroinflammation plays a major role in the etiopathology of neurodegenerative diseases,
including Alzheimer and Parkinson diseases, frontotemporal lobar degeneration, and …

Abstract β-amyloid (Aβ) and tau aggregation as well as neuronal injury and atrophy (ATN)
are the major hallmarks of Alzheimer's disease (AD), and biomarkers for these hallmarks …

Background: In vivo PET/SPECT imaging of neuroinflammation is primarily based on the
estimation of the 18kDatranslocator-protein (TSPO). However, TSPO is expressed by …

Nonphysiologic overexpression of amyloid-β (Aβ) precursor protein in common transgenic
Aβ mouse models of Alzheimer disease likely hampers their translational potential. The …