[HTML][HTML] Quantification of amyloid PET for future clinical use: a state-of-the-art review

HG Pemberton, LE Collij, F Heeman, A Bollack… - European journal of …, 2022 - Springer
Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer's
disease (AD) pathogenesis. The overall load and spatial distribution of brain Aβ can be …

[HTML][HTML] The use, standardization, and interpretation of brain imaging data in clinical trials of neurodegenerative disorders

AJ Schwarz - Neurotherapeutics, 2021 - Elsevier
Imaging biomarkers play a wide-ranging role in clinical trials for neurological disorders. This
includes selecting the appropriate trial participants, establishing target engagement and …

Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer's disease

AV Venkataraman, A Mansur, G Rizzo… - Science Translational …, 2022 - science.org
Cell stress and impaired oxidative phosphorylation are central to mechanisms of synaptic
loss and neurodegeneration in the cellular pathology of Alzheimer's disease (AD). In this …

Direct comparison of the tau PET tracers 18F-flortaucipir and 18F-MK-6240 in human subjects

A Gogola, DS Minhas, VL Villemagne… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Tau PET tracers exhibit varying levels of specific signal and distinct off-target binding
patterns that are more diverse than amyloid PET tracers. This study compared 2 frequently …

[HTML][HTML] Selecting software pipelines for change in flortaucipir SUVR: Balancing repeatability and group separation

CG Schwarz, TM Therneau, SD Weigand, JL Gunter… - Neuroimage, 2021 - Elsevier
Since tau PET tracers were introduced, investigators have quantified them using a wide
variety of automated methods. As longitudinal cohort studies acquire second and third time …

[HTML][HTML] Validation of quantitative assessment of florbetaben PET scans as an adjunct to the visual assessment across 15 software methods

A Jovalekic, N Roé-Vellvé, N Koglin… - European Journal of …, 2023 - Springer
Purpose Amyloid positron emission tomography (PET) with [18F] florbetaben (FBB) is an
established tool for detecting Aβ deposition in the brain in vivo based on visual assessment …

[HTML][HTML] β-amyloid PET harmonisation across longitudinal studies: Application to AIBL, ADNI and OASIS3

P Bourgeat, V Doré, SC Burnham, T Benzinger… - Neuroimage, 2022 - Elsevier
Abstract Introduction The Centiloid scale was developed to harmonise the quantification of β-
amyloid (Aβ) PET images across tracers, scanners, and processing pipelines. However …

Improving PET imaging acquisition and analysis with machine learning: a narrative review with focus on Alzheimer's disease and oncology

IR Duffy, AJ Boyle, N Vasdev - Molecular imaging, 2019 - journals.sagepub.com
Machine learning (ML) algorithms have found increasing utility in the medical imaging field
and numerous applications in the analysis of digital biomarkers within positron emission …

Amyloid accumulation in Down syndrome measured with amyloid load

MD Zammit, CM Laymon, TJ Betthauser… - Alzheimer's & …, 2020 - Wiley Online Library
Abstract Introduction Individuals with Down syndrome (DS) show enhanced amyloid beta
(Aβ) deposition in the brain. A new positron emission tomography (PET) index of amyloid …

[HTML][HTML] A multisite analysis of the concordance between visual image interpretation and quantitative analysis of [18F]flutemetamol amyloid PET images

M Bucci, I Savitcheva, G Farrar, G Salvadó… - European journal of …, 2021 - Springer
Background [18 F] flutemetamol PET scanning provides information on brain amyloid load
and has been approved for routine clinical use based upon visual interpretation as either …