[HTML][HTML] Recent advances of PET imaging in clinical radiation oncology
M Unterrainer, C Eze, H Ilhan, S Marschner… - Radiation …, 2020 - Springer
Radiotherapy and radiation oncology play a key role in the clinical management of patients
suffering from oncological diseases. In clinical routine, anatomic imaging such as contrast …
suffering from oncological diseases. In clinical routine, anatomic imaging such as contrast …
Image guidance in radiation therapy for better cure of cancer
V Grégoire, M Guckenberger… - Molecular …, 2020 - Wiley Online Library
The key goal and main challenge of radiation therapy is the elimination of tumors without
any concurring damages of the surrounding healthy tissues and organs. Radiation doses …
any concurring damages of the surrounding healthy tissues and organs. Radiation doses …
[HTML][HTML] Quantitative imaging for radiotherapy purposes
OJ Gurney-Champion, F Mahmood, M van Schie… - Radiotherapy and …, 2020 - Elsevier
Quantitative imaging biomarkers show great potential for use in radiotherapy. Quantitative
images based on microscopic tissue properties and tissue function can be used to improve …
images based on microscopic tissue properties and tissue function can be used to improve …
[HTML][HTML] Dose escalation to hypoxic subvolumes in head and neck cancer: A randomized phase II study using dynamic [18F] FMISO PET/CT
S Welz, F Paulsen, C Pfannenberg, M Reimold… - Radiotherapy and …, 2022 - Elsevier
Background and purpose Tumor hypoxia is a major cause of resistance to
radiochemotherapy in locally advanced head-and-neck cancer (LASCCHN). We present …
radiochemotherapy in locally advanced head-and-neck cancer (LASCCHN). We present …
[HTML][HTML] Imaging of tumor hypoxia with radionuclide-labeled tracers for PET
Y Huang, J Fan, Y Li, S Fu, Y Chen, J Wu - Frontiers in Oncology, 2021 - frontiersin.org
The hypoxic state in a solid tumor refers to the internal hypoxic environment that appears as
the tumor volume increases (the maximum radius exceeds 180-200 microns). This state can …
the tumor volume increases (the maximum radius exceeds 180-200 microns). This state can …
Imaging of tumor hypoxia for radiotherapy: current status and future directions
M Busk, J Overgaard, MR Horsman - Seminars in nuclear medicine, 2020 - Elsevier
Tumor regions that are transiently or chronically undersupplied with oxygen (hypoxia) and
nutrients, and enriched with acidic waste products, are common due to an abnormal and …
nutrients, and enriched with acidic waste products, are common due to an abnormal and …
[HTML][HTML] Machine learning identifies multi-parametric functional PET/MR imaging cluster to predict radiation resistance in preclinical head and neck cancer models
S Boeke, RM Winter, S Leibfarth, MA Krueger… - European Journal of …, 2023 - Springer
Purpose Tumor hypoxia and other microenvironmental factors are key determinants of
treatment resistance. Hypoxia positron emission tomography (PET) and functional magnetic …
treatment resistance. Hypoxia positron emission tomography (PET) and functional magnetic …
[HTML][HTML] Advances in PET and MRI imaging of tumor hypoxia
Tumor hypoxia is a complex and evolving phenomenon both in time and space. Molecular
imaging allows to approach these variations, but the tracers used have their own limitations …
imaging allows to approach these variations, but the tracers used have their own limitations …
Hypoxia-Directed Treatment of Human Papillomavirus–Related Oropharyngeal Carcinoma
NY Lee, EJ Sherman, HK Schöder… - Journal of Clinical …, 2024 - ingentaconnect.com
PURPOSE Standard curative-intent chemoradiotherapy for human papillomavirus (HPV)–
related oropharyngeal carcinoma results in significant toxicity. Since hypoxic tumors are …
related oropharyngeal carcinoma results in significant toxicity. Since hypoxic tumors are …
[HTML][HTML] Synthesis of [18F]FMISO, a hypoxia-specific imaging probe for PET, an overview from a radiochemist's perspective
T Kniess, J Zessin, P Mäding, M Kuchar, O Kiss… - EJNMMI …, 2023 - Springer
Abstract Background [18F] fluoromisonidazole ([18F] FMISO, 1 H-1-(3-[18F] fluoro-2-
hydroxypropyl)-2-nitroimidazole) is a commonly used radiotracer for imaging hypoxic …
hydroxypropyl)-2-nitroimidazole) is a commonly used radiotracer for imaging hypoxic …