Imaging-guided targeted radionuclide tumor therapy: From concept to clinical translation
J Sun, Z Huangfu, J Yang, G Wang, K Hu, M Gao… - Advanced Drug Delivery …, 2022 - Elsevier
Since the first introduction of sodium iodide I-131 for use with thyroid patients almost 80
years ago, more than 50 radiopharmaceuticals have reached the markets for a wide range …
years ago, more than 50 radiopharmaceuticals have reached the markets for a wide range …
[HTML][HTML] Lighting up the tumor fire with low-dose irradiation
FG Herrera, P Romero, G Coukos - Trends in Immunology, 2022 - cell.com
Current efforts combining immunotherapy and radiation have focused on high-dose
radiation delivered to few tumor lesions, aiming to generate diffuse abscopal effects; …
radiation delivered to few tumor lesions, aiming to generate diffuse abscopal effects; …
Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade
RB Patel, R Hernandez, P Carlson… - Science translational …, 2021 - science.org
Molecular and cellular effects of radiotherapy on tumor microenvironment (TME) can help
prime and propagate antitumor immunity. We hypothesized that delivering radiation to all …
prime and propagate antitumor immunity. We hypothesized that delivering radiation to all …
[HTML][HTML] Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy
Rationale: Clinical interest in combining targeted radionuclide therapies (TRT) with
immunotherapies is growing. External beam radiation therapy (EBRT) activates a type 1 …
immunotherapies is growing. External beam radiation therapy (EBRT) activates a type 1 …
[HTML][HTML] Clinical advances and perspectives in targeted radionuclide therapy
N Lepareur, B Ramée, M Mougin-Degraef… - Pharmaceutics, 2023 - mdpi.com
Targeted radionuclide therapy has become increasingly prominent as a nuclear medicine
subspecialty. For many decades, treatment with radionuclides has been mainly restricted to …
subspecialty. For many decades, treatment with radionuclides has been mainly restricted to …
[HTML][HTML] Safety and feasibility of an in situ vaccination and immunomodulatory targeted radionuclide combination immuno-radiotherapy approach in a comparative …
K Magee, IR Marsh, MM Turek, J Grudzinski… - PLoS …, 2021 - journals.plos.org
Rationale Murine syngeneic tumor models have revealed efficacious systemic antitumor
responses following primary tumor in situ vaccination combined with targeted radionuclide …
responses following primary tumor in situ vaccination combined with targeted radionuclide …
[HTML][HTML] Antitumor efficacy of 90Y-NM600 targeted radionuclide therapy and PD-1 blockade is limited by regulatory T cells in murine prostate tumors
Background Systemic radiation treatments that preferentially irradiate cancer cells over
normal tissue, known as targeted radionuclide therapy (TRT), have shown significant …
normal tissue, known as targeted radionuclide therapy (TRT), have shown significant …
177Lu-NM600 targeted radionuclide therapy extends survival in syngeneic murine models of triple-negative breast cancer
R Hernandez, JJ Grudzinski… - Journal of Nuclear …, 2020 - Soc Nuclear Med
There is a clinically unmet need for effective treatments for triple-negative breast cancer
(TNBC), as it remains the most aggressive subtype of breast cancer. Herein, we demonstrate …
(TNBC), as it remains the most aggressive subtype of breast cancer. Herein, we demonstrate …
Next-generation cancer magnetic resonance imaging with tumor-targeted alkylphosphocholine metal analogs
RR Zhang, C Choi, CL Brunnquell… - Investigative …, 2022 - journals.lww.com
Objectives In an effort to exploit the elevated need for phospholipids displayed by cancer
cells relative to normal cells, we have developed tumor-targeted alkylphosphocholines …
cells relative to normal cells, we have developed tumor-targeted alkylphosphocholines …
Low-Dose Radiation Potentiates the Propagation of Anti-Tumor Immunity against Melanoma Tumor in the Brain after In Situ Vaccination at a Tumor outside the Brain
PA Clark, RN Sriramaneni, AM Bates… - Radiation …, 2021 - meridian.allenpress.com
Brain metastases develop in over 60% of advanced melanoma patients and negatively
impact quality of life and prognosis. In a murine melanoma model, we previously showed …
impact quality of life and prognosis. In a murine melanoma model, we previously showed …