Since the first introduction of sodium iodide I-131 for use with thyroid patients almost 80
years ago, more than 50 radiopharmaceuticals have reached the markets for a wide range …

Current efforts combining immunotherapy and radiation have focused on high-dose
radiation delivered to few tumor lesions, aiming to generate diffuse abscopal effects; …

Molecular and cellular effects of radiotherapy on tumor microenvironment (TME) can help
prime and propagate antitumor immunity. We hypothesized that delivering radiation to all …

Rationale: Clinical interest in combining targeted radionuclide therapies (TRT) with
immunotherapies is growing. External beam radiation therapy (EBRT) activates a type 1 …

Targeted radionuclide therapy has become increasingly prominent as a nuclear medicine
subspecialty. For many decades, treatment with radionuclides has been mainly restricted to …

Rationale Murine syngeneic tumor models have revealed efficacious systemic antitumor
responses following primary tumor in situ vaccination combined with targeted radionuclide …

Background Systemic radiation treatments that preferentially irradiate cancer cells over
normal tissue, known as targeted radionuclide therapy (TRT), have shown significant …

There is a clinically unmet need for effective treatments for triple-negative breast cancer
(TNBC), as it remains the most aggressive subtype of breast cancer. Herein, we demonstrate …

Objectives In an effort to exploit the elevated need for phospholipids displayed by cancer
cells relative to normal cells, we have developed tumor-targeted alkylphosphocholines …

Brain metastases develop in over 60% of advanced melanoma patients and negatively
impact quality of life and prognosis. In a murine melanoma model, we previously showed …