[HTML][HTML] Integrins in cancer: Emerging mechanisms and therapeutic opportunities

F Liu, Q Wu, Z Dong, K Liu - Pharmacology & therapeutics, 2023 - Elsevier
Integrins are vital surface adhesion receptors that mediate the interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …

[HTML][HTML] PET Diagnostic Molecules Utilizing Multimeric Cyclic RGD Peptide Analogs for Imaging Integrin αvβ3 Receptors

C Liolios, C Sachpekidis, A Kolocouris… - Molecules, 2021 - mdpi.com
Multimeric ligands consisting of multiple pharmacophores connected to a single backbone
have been widely investigated for diagnostic and therapeutic applications. In this review, we …

[HTML][HTML] Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice

JP Sundberg, CH Pratt, LP Goodwin, KA Silva… - PLoS …, 2020 - journals.plos.org
Spontaneous mutations in the SHANK-associated RH domain interacting protein (Sharpin)
resulted in a severe autoinflammatory type of chronic proliferative dermatitis, inflammation in …

SHARPIN: Role in Finding NEMO and in Amyloid-Beta Clearance and Degradation (ABCD) Pathway in Alzheimer's Disease?

D Krishnan, RN Menon, S Gopala - Cellular and Molecular Neurobiology, 2022 - Springer
SHANK-associated RH domain-interacting protein (SHARPIN) is a multifunctional protein
associated with numerous physiological functions and many diseases. The primary role of …

[HTML][HTML] In vivo imaging of biodegradable implants and related tissue biomarkers

L Riehakainen, C Cavallini, P Armanetti, D Panetta… - Polymers, 2021 - mdpi.com
Non-invasive longitudinal imaging of osseointegration of bone implants is essential to
ensure a comprehensive, physical and biochemical understanding of the processes related …

Recent progress in functional peptides designed for tumor-targeted imaging and therapy

XY Wang, YH Wang, Z Song, XY Hu, JP Wei… - Journal of Materials …, 2021 - pubs.rsc.org
The diagnosis and therapy of tumors are challenging problems in the medical field. Peptides
are derived from living organisms with excellent biocompatibility, low-toxicity/non-toxicity …

[HTML][HTML] Beyond Small Molecules: Antibodies and Peptides for Fibroblast Activation Protein Targeting Radiopharmaceuticals

X Sun, Y Wu, X Wang, X Gao, S Zhang, Z Sun, R Liu… - Pharmaceutics, 2024 - mdpi.com
Fibroblast activation protein (FAP) is a serine protease characterized by its high expression
in cancer-associated fibroblasts (CAFs) and near absence in adult normal tissues and …

[HTML][HTML] In vivo nano contrast-enhanced photoacoustic imaging for dynamically lightening the molecular changes of rheumatoid arthritis

S Xiao, Y Tang, Y Lin, Z Lv, L Chen - Materials & Design, 2021 - Elsevier
Rheumatoid arthritis (RA) is one of the most prevalent inflammatory joint disorders. Early
diagnosis, accurate staging, and imaging guided treatment response of RA remain crucial …

[HTML][HTML] [68Ga]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice

R Viitanen, H Virtanen, H Liljenbäck, O Moisio… - Frontiers in …, 2022 - frontiersin.org
Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible adhesion molecule,
which supports contact between leukocytes and inflamed endothelium. There is evidence …

[HTML][HTML] Evaluation of [68Ga]Ga-NODAGA-RGD for PET Imaging of Rat Autoimmune Myocarditis

A Jahandideh, M Ståhle, J Virta, XG Li… - Frontiers in …, 2021 - frontiersin.org
The 68Gallium-labeled 1, 4, 7-triazacyclononane-1-glutaric acid-4, 7-diacetic acid
conjugated radiolabelled arginine-glycine-aspartic acid peptide ([68Ga] Ga-NODAGA-RGD) …