Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer's disease
BS Thawkar, G Kaur - Journal of neuroimmunology, 2019 - Elsevier
Microglial activation is a distinguished attribute in many neurodegenerative diseases of
aging. Compelling evidence suggests that neuroinflammation stimulated by microglia, the …
aging. Compelling evidence suggests that neuroinflammation stimulated by microglia, the …
The repertoire of small-molecule PET probes for neuroinflammation imaging: challenges and opportunities beyond TSPO
Neuroinflammation is an adaptive response of the central nervous system to diverse
potentially injurious stimuli, which is closely associated with neurodegeneration and …
potentially injurious stimuli, which is closely associated with neurodegeneration and …
Purinergic receptors of the central nervous system: biology, PET ligands, and their applications
H Zarrinmayeh, PR Territo - Molecular Imaging, 2020 - journals.sagepub.com
Purinergic receptors play important roles in central nervous system (CNS). These receptors
are involved in cellular neuroinflammatory responses that regulate functions of neurons …
are involved in cellular neuroinflammatory responses that regulate functions of neurons …
[11C]JNJ54173717, a novel P2X7 receptor radioligand as marker for neuroinflammation: human biodistribution, dosimetry, brain kinetic modelling and quantification …
D Van Weehaeghe, M Koole, ME Schmidt… - European Journal of …, 2019 - Springer
Abstract Purpose The P2X7 receptor (P2X7R) is an ATP-gated ion channel predominantly
expressed on activated microglia and is important in neurodegenerative diseases including …
expressed on activated microglia and is important in neurodegenerative diseases including …
[HTML][HTML] The coming of age of the P2X7 receptor in diagnostic medicine
F Di Virgilio, V Vultaggio-Poma, S Falzoni… - International Journal of …, 2023 - mdpi.com
The discovery of the P2X7 receptor (P2X7R, originally named P2Z) in immune cells, its
cloning, and the identification of its role in a multiplicity of immune-mediated diseases raised …
cloning, and the identification of its role in a multiplicity of immune-mediated diseases raised …
[HTML][HTML] P2X7 Receptors in Neurodegeneration: Potential Therapeutic Applications From Basic to Clinical Approaches
PR Territo, H Zarrinmayeh - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Purinergic receptors play important roles in central nervous system (CNS), where the bulk of
these receptors are implicated in neuroinflammatory responses and regulation of cellular …
these receptors are implicated in neuroinflammatory responses and regulation of cellular …
[HTML][HTML] PET Imaging of the P2X7 Ion Channel with a Novel Tracer [18F]JNJ-64413739 in a Rat Model of Neuroinflammation
T Berdyyeva, C Xia, N Taylor, Y He, G Chen… - Molecular Imaging and …, 2019 - Springer
Abstract Purpose The P2X7 receptor, an adenosine triphosphate (ATP)-gated
purinoreceptor, has emerged as one of the key players in neuroinflammatory processes …
purinoreceptor, has emerged as one of the key players in neuroinflammatory processes …
PET Imaging of P2X7 Receptor (P2X7R) for Neuroinflammation with Improved Radiosynthesis of Tracer [18F]4A in Mice and Non-human Primates
G Huang, Y Qiu, L Bi, H Wei, G Li, Z Li… - ACS Chemical …, 2022 - ACS Publications
The P2X7 receptor (P2X7R) is a key neuroinflammation target in a variety of
neurodegenerative diseases. Improved radiosynthesis was developed according to the …
neurodegenerative diseases. Improved radiosynthesis was developed according to the …
[HTML][HTML] Spotlight on P2X7 Receptor PET Imaging: A Bright Target or a Failing Star?
S Schmidt, A Isaak, A Junker - International journal of molecular sciences, 2023 - mdpi.com
The homotrimeric P2X7 receptor (P2X7R) is expressed by virtually all cells of the innate and
adaptive immune system and plays a crucial role in various pathophysiological processes …
adaptive immune system and plays a crucial role in various pathophysiological processes …
Beyond monoamines: I. Novel targets and radiotracers for Positron emission tomography imaging in psychiatric disorders
With the emergence of positron emission tomography (PET) in the late 1970s, psychiatry
had access to a tool capable of non‐invasive assessment of human brain function. Early …
had access to a tool capable of non‐invasive assessment of human brain function. Early …