[HTML][HTML] Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
Neurotransmitter receptors support the propagation of signals in the human brain. How
receptor systems are situated within macro-scale neuroanatomy and how they shape …
receptor systems are situated within macro-scale neuroanatomy and how they shape …
[HTML][HTML] Local molecular and global connectomic contributions to cross-disorder cortical abnormalities
Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …
arise from molecular perturbations or connectome miswiring. The unique and shared …
Synaptic changes in Parkinson disease assessed with in vivo imaging
D Matuskey, S Tinaz, KC Wilcox… - Annals of …, 2020 - Wiley Online Library
Objective Parkinson disease is characterized by motor and nonmotor symptoms, reduced
striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now …
striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now …
[HTML][HTML] Revealing the neurobiology underlying interpersonal neural synchronization with multimodal data fusion
Humans synchronize with one another to foster successful interactions. Here, we use a
multimodal data fusion approach with the aim of elucidating the neurobiological …
multimodal data fusion approach with the aim of elucidating the neurobiological …
Dual-acting agents for improving cognition and real-world function in Alzheimer's disease: Focus on 5-HT6 and D3 receptors as hubs
MJ Millan, A Dekeyne, A Gobert, M Brocco… - …, 2020 - Elsevier
To date, there are no interventions that impede the inexorable progression of Alzheimer's
disease (AD), and currently-available drugs cholinesterase (AChE) inhibitors and the N …
disease (AD), and currently-available drugs cholinesterase (AChE) inhibitors and the N …
In vivo mapping of pharmacologically induced functional reorganization onto the human brain's neurotransmitter landscape
To understand how pharmacological interventions can exert their powerful effects on brain
function, we need to understand how they engage the brain's rich neurotransmitter …
function, we need to understand how they engage the brain's rich neurotransmitter …
[HTML][HTML] Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain
Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter
receptors and transporters play a key role in shaping brain function. Due to the lack of …
receptors and transporters play a key role in shaping brain function. Due to the lack of …
[HTML][HTML] Assortative mixing in micro-architecturally annotated brain connectomes
The wiring of the brain connects micro-architecturally diverse neuronal populations, but the
conventional graph model, which encodes macroscale brain connectivity as a network of …
conventional graph model, which encodes macroscale brain connectivity as a network of …
[HTML][HTML] Transitions between cognitive topographies: contributions of network structure, neuromodulation, and disease
Patterns of neural activity underlie human cognition. Transitions between these patterns are
orchestrated by the brain's network architecture. What are the mechanisms linking network …
orchestrated by the brain's network architecture. What are the mechanisms linking network …
[HTML][HTML] Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties
J Staroń, R Kurczab, D Warszycki, G Satała… - European Journal of …, 2020 - Elsevier
A virtual screening campaign aimed at finding structurally new compounds active at 5-HT 6
R provided a set of candidates. Among those, one structure, 4-(5-{[(2-{5-fluoro-1H-pyrrolo [2 …
R provided a set of candidates. Among those, one structure, 4-(5-{[(2-{5-fluoro-1H-pyrrolo [2 …