Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …

Parkinson's disease (PD) is a neurodegenerative disorder that affects millions of people
worldwide. Two hallmarks of PD are the accumulation of alpha‐synuclein and the loss of …

Background Accumulating evidence suggests that α-synuclein aggregates—a defining
pathology of Parkinson's disease—display cell-to-cell transmission. α-synuclein aggregation …

Previous studies have reported substantial involvement of the noradrenergic system in
Parkinson's disease. Neuromelanin-sensitive MRI sequences and PET tracers have become …

Pathological involvement of the noradrenergic locus coeruleus occurs early in Parkinson's
disease, and widespread noradrenaline reductions are found at post-mortem. Rapid eye …

Many advances in understanding the pathophysiology of Parkinson disease (PD) have been
based on research addressing its motor symptoms and phenotypes. Various data-driven …

The locus coeruleus (LC) has long been underappreciated for its role in the pathophysiology
of Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative …

Induced pluripotent stem cell-derived organoids offer an unprecedented access to complex
human tissues that recapitulate features of architecture, composition and function of in vivo …

Primary prevention trials have shifted their focus to the earliest stages of Alzheimer's disease
(AD). Autopsy data indicates that the neuromodulatory subcortical systems'(NSS) nuclei are …

Noradrenaline (NA) in the thalamus has important roles in physiological, pharmacological,
and pathological neuromodulation. In this work, a complete characterization of NA axons …