Cancer development is highly associated to the physiological state of the tumor
microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from …

Triple negative breast cancer (TNBC) is most aggressive subtype of breast cancers with high
probability of metastasis as well as lack of specific targets and targeted therapeutics. TNBC …

Tumors are surrounded by complex environmental components, including blood and lymph
vessels, fibroblasts, endothelial cells, immune cells, cytokines, extracellular vesicles, and …

Owing to improvements in our understanding of the biological principles of tumour initiation
and progression, a wide variety of novel targeted therapies have been developed …

Immunotherapy has recently emerged as a novel strategy for treating different types of solid
tumors, with promising results. However, still a large fraction of patients do not primarily …

Treatment of triple-negative breast cancer (TNBC) remains challenging because of the
heterogeneity of the disease and lack of single targetable driving mutations. TNBC does not …

With further research into the molecular mechanisms and roles linking immune suppression
and restraint of (pre) malignancies, immunotherapies have revolutionized clinical strategies …

Triple-negative breast cancer (TNBC) is defined based on the absence of estrogen,
progesterone, and human epidermal growth factor receptor 2 receptors. Currently …

Advanced knowledge about the role of tumor microenvironment (TME) in cancer
progression has opened various ways to target the vast signaling pathways for cancer …

Introduction Triple negative breast cancer is typically related to poor prognosis, early
metastasis, and high recurrence rate. Intrinsic and extrinsic biological features of TNBC and …