Neuroinflammation is a multifaceted physiological and pathophysiological response of the
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …

Neuroinflammation is a key pathologic hallmark of numerous neurologic diseases, however,
its exact role in vivo is yet to be fully understood. PET imaging enables investigation …

Introduction Ischemia–reperfusion injury (IRI) is the inexplicable aggravation of cellular
dysfunction that results in blood flow restoration to previously ischemic tissues. COX …

Activation of innate immune cells and other compartmentalized inflammatory cells in the
brains and spinal cords of people with relapsing–remitting multiple sclerosis (MS) and …

Purpose: Reactive microglia are an important hallmark of neuroinflammation. Reactive
microglia release various inflammatory mediators, such as cytokines, chemokines, and …

Neuroinflammation is an adaptive response of the central nervous system to diverse
potentially injurious stimuli, which is closely associated with neurodegeneration and …

Colony-stimulating factor 1 receptor (CSF1R) is a specific biomarker for microglia. In this
study, we developed a novel PET radioligand for CSF1R, 11C-GW2580, and compared it to …

There is increasing evidence showing the heterogeneity of microglia activation in
neuroinflammatory and neurodegenerative diseases. It has been hypothesized that pro …

Behçet's syndrome (BS) is a systemic vasculitis with several clinical manifestations.
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …

Abstract Background Cyclooxygenase-2 (COX-2), which is rapidly upregulated by
inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several …