Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …

Amyloid-beta and tau are key molecules in the pathogenesis of Alzheimer's disease, but it
remains unclear how these proteins interact to promote disease. Here, by combining cross …

β-Amyloid plaques and tau-containing neurofibrillary tangles are the two neuropathological
hallmarks of Alzheimer's disease (AD) and are thought to play crucial roles in a …

Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …

Objective To determine the rate of tau accumulation in healthy older adults (OA) and patients
with Alzheimer disease (AD), as well as the relationship of tau accumulation to cortical …

The aggregation of fibrils of hyperphosphorylated and C-terminally truncated microtubule-
associated tau protein characterizes 80% of all dementia disorders, the most common …

This study investigated differences in retrospective cognitive trajectories between amyloid
and tau PET biomarker stratified groups in initially cognitively unimpaired participants …

Quantitative susceptibility mapping (QSM) has been used to study susceptibility changes
that may occur based on tissue composition and mineral deposition. Iron is a primary …

Purpose To provide an overview on positron emission tomography (PET) imaging of tau
pathology in Alzheimer's disease (AD) and other neurodegenerative disorders. Results …