ImmunoPET: concept, design, and applications

W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

[HTML][HTML] Nanobodies: next generation of cancer diagnostics and therapeutics

EY Yang, K Shah - Frontiers in Oncology, 2020 - frontiersin.org
The development of targeted medicine has greatly expanded treatment options and spurred
new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging …

[HTML][HTML] Nanobody: a promising toolkit for molecular imaging and disease therapy

G Bao, M Tang, J Zhao, X Zhu - EJNMMI research, 2021 - Springer
Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with
many unique properties such as small size, excellent solubility, superior stability, quick …

[PDF][PDF] Nanobody—A versatile tool for cancer diagnosis and therapeutics

M Liu, L Li, D Jin, Y Liu - Wiley Interdisciplinary Reviews …, 2021 - researchgate.net
In spite of the successful use of monoclonal antibodies (mAbs) in clinic for tumor treatment,
their applications are still hampered in therapeutic development due to limitations, such as …

[HTML][HTML] Nanobody engineering: toward next generation immunotherapies and immunoimaging of cancer

T Chanier, P Chames - Antibodies, 2019 - mdpi.com
In the last decade, cancer immunotherapies have produced impressive therapeutic results.
However, the potency of immunotherapy is tightly linked to immune cell infiltration within the …

Nanobodies as molecular imaging probes

S Barakat, M Berksöz, P Zahedimaram, S Piepoli… - Free Radical Biology …, 2022 - Elsevier
Camelidae derived single-domain antibodies (sdAbs), commonly known as nanobodies
(Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their …

Antibody fragment and affibody immunoPET imaging agents: radiolabelling strategies and applications

R Fu, L Carroll, G Yahioglu, EO Aboagye… - …, 2018 - Wiley Online Library
Antibodies have long been recognised as potent vectors for carrying diagnostic medical
radionuclides, contrast agents and optical probes to diseased tissue for imaging. The area of …

[HTML][HTML] Targeted nanobody-based molecular tracers for nuclear imaging and image-guided surgery

P Debie, N Devoogdt, S Hernot - Antibodies, 2019 - mdpi.com
Molecular imaging is paving the way towards noninvasive detection, staging, and treatment
follow-up of diseases such as cancer and inflammation-related conditions. Monoclonal …

[HTML][HTML] ImmunoPET: antibody-based PET imaging in solid tumors

R Manafi-Farid, B Ataeinia, S Ranjbar… - Frontiers in …, 2022 - frontiersin.org
Immuno-positron emission tomography (immunoPET) is a molecular imaging modality
combining the high sensitivity of PET with the specific targeting ability of monoclonal …

[HTML][HTML] Single-domain antibodies and the promise of modular targeting in cancer imaging and treatment

ME Iezzi, L Policastro, S Werbajh, O Podhajcer… - Frontiers in …, 2018 - frontiersin.org
Monoclonal antibodies and their fragments have significantly changed the outcome of
cancer in the clinic, effectively inhibiting tumor cell proliferation, triggering antibody …