Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the
substantia nigra pars compacta (SNpc) and the appearance of α-synuclein insoluble …

Introduction Overpopulation and industrial growth result in an increase in air pollution,
mainly due to suspended particulate matter and the formation of ozone. Repeated exposure …

After advanced age, female sex is the major risk factor for Alzheimer's disease (AD). The
biological mechanisms underlying the increased AD risk in women remain largely …

Background Dysfunction of mitochondrial energy generation may contribute to
neurodegeneration, leading to synaptic loss in Parkinson's disease (PD). The objective of …

There is a need to disentangle the etiological puzzle of age-related neurodegenerative
diseases, whose clinical phenotypes arise from known, and as yet unknown, pathways that …

Alpha-synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies and
multiple system atrophy, are characterized by aberrant accumulation of alpha-synuclein and …

Parkinson's disease (PD) is a debilitating neurodegenerative multisystem disorder leading
to motor and non-motor symptoms in millions of individuals. Despite intense research, there …

Mitochondrial complex I (MC-I) is an essential component of brain bioenergetics and can be
quantified and studied using positron emission tomography (PET). A specific high affinity …

Decreased cortical serotonergic and catecholaminergic innervation of the frontal cortex has
been reported at early stages of Parkinson's disease (PD). However, the limited availability …

Hydroxydopamine (6-OHDA), a synthetic neurotoxin, has been used to generate animal
models of Parkinson's disease (PD). Even though 6-OHDA induced neurodegenerative …