Recent achievements in Tc-99m radiopharmaceutical direct production by medical cyclotrons

A Boschi, P Martini, M Pasquali… - Drug development and …, 2017 - Taylor & Francis
Abstract 99mTc is the most commonly used radionuclide in the field of diagnostic imaging, a
noninvasive method intended to diagnose a disease, assess the disease state and monitor …

[HTML][HTML] Nuclear imaging for immune cell tracking in vivo–Comparison of various cell labeling methods and their application

Ł Kiraga, P Kucharzewska, S Paisey, Ł Cheda… - Coordination chemistry …, 2021 - Elsevier
There is currently great interest in the development of cell-based therapies, particularly
those focused on the idea of exploiting systemically administered immune cells for …

Internal radiation dose assessment of radiopharmaceuticals prepared with cyclotron‐produced 99mTc

L Meléndez‐Alafort, G Ferro‐Flores… - Medical …, 2019 - Wiley Online Library
Purpose Technetium‐99m (99mTc) is the radioisotope most widely used in diagnostic
nuclear medicine. It is readily available from 99Mo/99mTc generators as the β− decay …

A preliminary biodistribution study of [99mTc] sodium pertechnetate prepared from an electron linear accelerator and activated carbon-based 99mTc generator

J Jang, Y Kumakura, K Tatenuma, AN Ozeki… - Nuclear Medicine and …, 2022 - Elsevier
Abstract Introduction Production of 99 Mo/99m Tc using an electron linear accelerator (linac)
and activated carbon (AC)-based 99m Tc generator (linac-AC) is an alternative approach to …

Robust high-yield~ 1 TBq production of cyclotron based sodium [99mTc] pertechnetate

JD Andersson, B Thomas, SV Selivanova… - Nuclear medicine and …, 2018 - Elsevier
This paper presents the irradiation and processing of high-current 100 Mo targets at the
University of Alberta (UofA) in a GMP compliant setting. For purpose of comparison with a …

Design and testing of a W-MoO3 target system for electron linac production of 99Mo/99mTc

J Jang, H Kikunaga, S Sekimoto, M Inagaki… - Nuclear Instruments and …, 2021 - Elsevier
To improve the efficiency of electron linear accelerator production of 99 Mo/99m Tc, a W-
MoO 3 target system was designed and its 99 Mo production performance was tested …

Methods for the production of radionuclides for medicine

LL Radford, SE Lapi - Radiopharmaceutical Chemistry, 2019 - Springer
Nuclear reactions involve the interaction of particles or photons with the nuclei of target
atoms, resulting in the production of radioactive atoms that can be used in medicine for …

Possible impurities in radiopharmaceuticals and corresponding test methods

GE Kodina, AO Malysheva… - Bulletin of the …, 2022 - vedomostincesmp.ru
The main quality attributes of radiopharmaceuticals that ensure their effectiveness and
safety and are unique to their specifications are activity, radionuclide identity, radionuclide …

Radiochemical purity and stability of 99mTc-HMPAO in routine preparations

L Uccelli, P Martini, M Pasquali, A Boschi - Journal of Radioanalytical and …, 2017 - Springer
The aim of this work was to investigate the influence of pH, recovery volume, type of saline
solution plastic or glass container, used to prepare the technetium-99m-d, l …

Development and pre-clinical evaluation of new 99Mo/99mTc generator prototype based on zirconium-based material (ZBM)

M Munir, E Lestari, K Karyadi, E Sarmini… - AIP Conference …, 2023 - pubs.aip.org
Zirconium-based material (ZBM) has been developed to overcome the shortage of
molybdenum-99 (99Mo) in the future. The material had been assembled in the generator's …