Abstract Astatine-211 (211 At, t 1/2= 7.21 h) emitting two α particles with energies of 5.87
and 7.45 MeV, can lead to a high linear energy transfer (LET= 98.84 keV/µm) and short …

With an increasing variety of radiopharmaceuticals for diagnostic or therapeutic nuclear
medicine as valuable diagnostic or treatment option, radiobiology plays an important role in …

Molecular biomarkers of ionizing radiation (IR) exposure are a promising new tool in various
disciplines: they can give necessary information for adaptive treatment planning in cancer …

α-Emission radiotherapeutics has potential to be one of most effective cancer therapeutics.
Herein, we report a facile synthesis of an 211At-labeled immunoconjugate for use as an α …

Background: Biological dosimetry is a novel approach in cancer radiotherapy and radiation
risk assessment that uses molecular biomarkers to reflect dose-response and inform …

Non-targeted effects can induce responses in tissues that have not been exposed to ionizing
radiation. Despite their relevance for risk assessment, few studies have investigated these …

High-throughput gene expression analysis is increasingly used in radiation research for
discovery of damage-related or absorbed dose-dependent biomarkers. In tissue samples …

Lung cancer is the world's largest cause of cancer mortality. Chemotherapy and radiation
have a very poor prognosis for individuals with advanced non-small cell lung cancer …

Radionuclides are widely used in medicine. 131I is one of the most employed radionuclides
and is administered to patients either bound to tumor targeting molecules or as halide to …

Molecular biomarkers of ionizing radiation (IR) exposure are a promising new tool in various
disciplines: they can give necessary information for adaptive treatment planning in cancer …