[HTML][HTML] Radiopharmaceuticals for PET and SPECT imaging: a literature review over the last decade

G Crișan, NS Moldovean-Cioroianu… - International Journal of …, 2022 - mdpi.com
Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

[HTML][HTML] PET imaging of neuroinflammation in Alzheimer's disease

R Zhou, B Ji, Y Kong, L Qin, W Ren, Y Guan… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …

PET imaging of neuroinflammation in neurological disorders

WC Kreisl, MJ Kim, JM Coughlin, ID Henter… - The Lancet …, 2020 - thelancet.com
A growing need exists for reliable in-vivo measurement of neuroinflammation to better
characterise the inflammatory processes underlying various diseases and to inform the …

[HTML][HTML] Recent developments in TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders

EL Werry, FM Bright, O Piguet, LM Ittner… - International journal of …, 2019 - mdpi.com
Neuroinflammation is an inflammatory response in the brain and spinal cord, which can
involve the activation of microglia and astrocytes. It is a common feature of many central …

[HTML][HTML] Recent developments on PET radiotracers for TSPO and their applications in neuroimaging

L Zhang, K Hu, T Shao, L Hou, S Zhang, W Ye… - … Pharmaceutica Sinica B, 2021 - Elsevier
The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …

The role of the immune system in Alzheimer's disease

KM Wu, YR Zhang, YY Huang, Q Dong, L Tan… - Ageing research …, 2021 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disorder where the
accumulation of amyloid plaques and the formation of tau tangles are the prominent …

Emerging PET radiotracers and targets for imaging of neuroinflammation in neurodegenerative diseases: outlook beyond TSPO

V Narayanaswami, K Dahl… - Molecular …, 2018 - journals.sagepub.com
The dynamic and multicellular processes of neuroinflammation are mediated by the
nonneuronal cells of the central nervous system, which include astrocytes and the brain's …

Radiological biomarkers for diagnosis in PSP: where are we and where do we need to be?

JL Whitwell, GU Höglinger, A Antonini… - Movement …, 2017 - Wiley Online Library
ABSTRACT PSP is a pathologically defined neurodegenerative tauopathy with a variety of
clinical presentations including typical Richardson's syndrome and other variant PSP …

[HTML][HTML] Translocator protein-18 kDa (TSPO) positron emission tomography (PET) imaging and its clinical impact in neurodegenerative diseases

AC Dupont, B Largeau, MJ Santiago Ribeiro… - International journal of …, 2017 - mdpi.com
In vivo exploration of activated microglia in neurodegenerative diseases is achievable by
Positron Emission Tomography (PET) imaging, using dedicated radiopharmaceuticals …

[HTML][HTML] PET neuroimaging of Alzheimer's disease: radiotracers and their utility in clinical research

W Bao, F Xie, C Zuo, Y Guan… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's Disease (AD), the leading cause of senile dementia, is a progressive
neurodegenerative disorder affecting millions of people worldwide and exerting tremendous …