Murine stroma adopts a human-like metabolic phenotype in the PDX model of colorectal cancer and liver metastases

A Blomme, G Van Simaeys, G Doumont, B Costanza… - Oncogene, 2018 - nature.com
Cancer research is increasingly dependent of patient-derived xenograft model (PDX).
However, a major point of concern regarding the PDX model remains the replacement of the …

Noninvasive Detection of HER2 Expression in Gastric Cancer by 64Cu-NOTA-Trastuzumab in PDX Mouse Model and in Patients

X Guo, H Zhu, N Zhou, Z Chen, T Liu, F Liu… - Molecular …, 2018 - ACS Publications
The purpose of this study was to establish the quality control and quantify the novel 64Cu-
NOTA-Trastuzumab in gastric cancer patient-derived xenografts (PDX) mice models and …

[HTML][HTML] PDXliver: a database of liver cancer patient derived xenograft mouse models

S He, B Hu, C Li, P Lin, WG Tang, YF Sun, FYM Feng… - BMC cancer, 2018 - Springer
Background Liver cancer is the second leading cause of cancer-related deaths and
characterized by heterogeneity and drug resistance. Patient-derived xenograft (PDX) …

[HTML][HTML] Metabolic classification of non-small cell lung cancer patient-derived xenografts by a digital pathology approach: A pilot study

F Ferrarini, E Zulato, M Moro, P Del Bianco… - Frontiers in …, 2023 - frontiersin.org
Genetically characterized patient-derived tumor xenografts (PDX) are a valuable resource to
understand the biological complexity of cancer and to investigate new therapeutic …

[HTML][HTML] Patient-derived xenografts, a multi-faceted in vivo model enlightening research on rare liver cancer biology

M Moro, M Casanova, L Roz - Hepatobiliary surgery and nutrition, 2017 - ncbi.nlm.nih.gov
© HepatoBiliary Surgery and Nutrition. All rights reserved. HepatoBiliary Surg Nutr 2017; 6
(5): 344-346 hbsn. amegroups. com with pediatric liver tumors are enrolled in clinical trials …

[HTML][HTML] Establishment of a [18F]-FDG-PET/MRI imaging protocol for gastric cancer PDX as a preclinical research tool

SW Bae, F Berlth, KY Jeong, YS Suh… - Journal of Gastric …, 2020 - ncbi.nlm.nih.gov
Purpose The utility of 18-fluordesoxyglucose positron emission tomography ([18 F]-FDG-
PET) combined with computer tomography or magnetic resonance imaging (MRI) in gastric …

Modeling the Tumor Microenvironment in Patient-Derived Xenografts: Challenges and Opportunities

K Kleinmanns, CH Gjerde, A Langer, V Fosse… - Biomarkers of the Tumor …, 2022 - Springer
The development of targeted and personalized therapies for cancer patients has underlined
the need for more advanced preclinical animal models to facilitate and favor clinical …

Characterization of sphere cells derived from a patient-derived xenograft model of lung adenocarcinoma treated with ionizing radiation

J Choi, EJ Ko, EJ Ju, SS Park, J Park… - … Journal of Radiation …, 2020 - Taylor & Francis
Abstract Purpose Cancer stem cells (CSCs) are relatively resistant to radiation compared to
their non-tumorigenic progeny. Ionizing radiation (IR) can expand the pool of CSCs that …

[PDF][PDF] 基于临床手术标本的胰腺癌原位移植模型建立及评价

张贺, 张彩勤, 赵勇, 谭邓旭, 师长宏 - 中国实验动物学报, 2018 - zgbjyx.cnjournals.com
目的建立基于临床肿瘤标本的胰腺癌原位移植模型, 开展模型的评价研究.
方法将临床新鲜的胰腺癌手术标本移植到裸鼠胰腺部位, 建立原位异种移植模型(PDOX) …

Advances in Patient Derived Tumor Xenograft (PDTX) Model from Lung Cancer.

QIN Baodong, J Xiaodong, Y Lingyan… - Chinese Journal of …, 2017 - search.ebscohost.com
With the development of tumor molecular biology and genomics, it has been recognized that
there are great heterogeneity in the biological characteristics, molecular typing and reactivity …