[HTML][HTML] Cerenkov luminescence imaging: physics principles and potential applications in biomedical sciences

E Ciarrocchi, N Belcari - EJNMMI physics, 2017 - Springer
Cerenkov luminescence imaging (CLI) is a novel imaging modality to study charged
particles with optical methods by detecting the Cerenkov luminescence produced in tissue …

Preclinical optimization of antibody‐based radiopharmaceuticals for cancer imaging and radionuclide therapy—Model, vector, and radionuclide selection

LM Carter, S Poty, SK Sharma… - Journal of Labelled …, 2018 - Wiley Online Library
Intact antibodies and their truncated counterparts (eg, Fab, scFv fragments) are generally
exquisitely specific and selective vectors, enabling recognition of individual cancer …

Synthesis and In Vivo Evaluation of a Site-specifically Labeled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas

TA Pringle, CD Chan, S Luli, HJ Blair… - Bioconjugate …, 2022 - ACS Publications
Bone sarcomas are devastating primary bone cancers that mostly affect children, young
adults, and the elderly. These aggressive tumors are associated with poor survival, and …

[HTML][HTML] A review of recent and emerging approaches for the clinical application of Cerenkov luminescence imaging

B Mc Larney, M Skubal, J Grimm - Frontiers in physics, 2021 - frontiersin.org
Cerenkov luminescence is a blue-weighted emission of light produced by a vast array of
clinically approved radioisotopes and LINAC accelerators. When β particles (emitted during …

Detection of shortwave-infrared Cerenkov luminescence from medical isotopes

BE Mc Larney, Q Zhang, EC Pratt… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Medical radioisotopes produce Cerenkov luminescence (CL) from charged subatomic
particles (β+/−) traveling faster than light in dielectric media (eg, tissue). CL is a blue …

Shortwave infrared detection of medical radioisotope Cerenkov luminescence.

B Mc Larney, Q Zhang, EC Pratt, M Skubal… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Rationale: Cerenkov luminescence (CL) is produced by medical radioisotopes when
charged particles (β+/-) travel faster than light in a dielectric medium (eg tissue). CLs blue …

Design of Cerenkov radiation–assisted photoactivation of TiO2 nanoparticles and reactive oxygen species generation for cancer treatment

S Kavadiya, P Biswas - Journal of Nuclear Medicine, 2019 - Soc Nuclear Med
The use of Cerenkov radiation to activate nanoparticles in situ was recently shown to control
cancerous tumor growth. Although the methodology has been demonstrated to work, to …

[HTML][HTML] In situ lymphoma imaging in a spontaneous mouse model using the Cerenkov Luminescence of F-18 and Ga-67 isotopes

Z Ritter, K Zámbó, P Balogh, D Szöllősi, X Jia… - Scientific reports, 2021 - nature.com
Cerenkov luminescence imaging (CLI) is a promising approach to image-guided surgery
and pathological sampling. It could offer additional advantages when combined to whole …

[HTML][HTML] Synthesis and preclinical evaluation of a 89Zr-labelled human single chain antibody for non-invasive detection of hepatic myofibroblasts in acute liver injury

TA Pringle, E Ramon-Gil, J Leslie, F Oakley… - Scientific Reports, 2024 - nature.com
Synaptophysin is expressed on fibrogenic hepatic myofibroblasts. C1–3 is a single chain
human antibody (scAb) that binds specifically to synaptophysin on hepatic myofibroblasts …

Comparative immuno-Cerenkov luminescence and-PET imaging enables detection of PSMA+ tumors in mice using 64Cu-radiolabeled monoclonal antibodies

FC Maier, AM Wild, N Kirchen, F Holm, K Fuchs… - Applied Radiation and …, 2019 - Elsevier
Here, we describe immuno-Cerenkov luminescence imaging (immuno-CLI) with a specific
monoclonal antibody-based tracer for the detection of prostate tumors, which is used in …