The translation of results from the preclinical to the clinical setting is often anything other
than straightforward. Indeed, ideas and even very intriguing results obtained at all levels of …

Considering the potential of PET imaging for precision medicine and drug development in
lung and other types of cancer, increasing efforts are warranted to standardize PET …

Purpose Preclinical in vivo nuclear imaging of mice offers an enabling perspective to
evaluate drug efficacy at optimal dose and schedule. In this study, we interrogated sufficient …

Molecular Metaphors is the application of squaryl building blocks towards creative functional
group chemistry to produce lead compounds and imaging agents. This strategy is applied to …

Purpose To image the uptake of cobalamin (Cbl) within malignant breast tumors in vivo.
Procedures Prior to surgery 20 female patients with clinically suspected breast tumors were …

Micronucleus (MN) assay constitutes a valuable surrogate to the chromosome aberration
technique for in vitro testing of the genotoxicity of substances. As test substances, two …

Androgen receptor (AR) activation is the primary driving factor in prostate cancer which is
initially responsive to castration but then becomes resistant (castration-resistant prostate …

Molecular imaging is defined as the visual representation, characterization, and
quantification of biological processes at the cellular and subcellular levels within intact living …

Androgen receptor (AR) activation is the primary driving factor in prostate cancer which is
initially responsive to castration but then becomes resistant (castration-resistant prostate …

Micronucleus (MN) assay constitutes a valuable surrogate to the chromosome aberration
technique for in vitro testing of the genotoxicity of substances. As test substances, two …