Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases

JA Hamilton, AD Cook, PP Tak - Nature reviews Drug discovery, 2017 - nature.com
Granulocyte–macrophage colony-stimulating factor (GM-CSF), macrophage colony-
stimulating factor (M-CSF; also known as CSF1), granulocyte colony-stimulating factor (G …

Effects of glycolysis on the polarization and function of tumor‑associated macrophages

J Cao, F Zeng, S Liao, L Cao… - … Journal of Oncology, 2023 - spandidos-publications.com
Under conditions of oxygen sufficiency, tumor cells supply themselves with energy through
glycolysis, which is one of the causes of their rapid proliferation, metastasis and acquisition …

Bone marrow mesenchymal stem cell-derived exosomes attenuate LPS-induced ARDS by modulating macrophage polarization through inhibiting glycolysis in …

H Deng, L Wu, M Liu, L Zhu, Y Chen, H Zhou, X Shi… - Shock, 2020 - journals.lww.com
Macrophages play a key role in the development of sepsis-induced acute respiratory
distress syndrome (ARDS). Recent evidence has proved that glycolysis plays an important …

[HTML][HTML] Inhibition of PFKFB3 hampers the progression of atherosclerosis and promotes plaque stability

K Poels, JG Schnitzler, F Waissi, JHM Levels… - Frontiers in cell and …, 2020 - frontiersin.org
Aims 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase (PFKFB) 3-mediated glycolysis
is pivotal in driving macrophage-and endothelial cell activation and thereby inflammation …

[HTML][HTML] Immunometabolism of phagocytes and relationships to cardiac repair

S Zhang, G Bories, C Lantz, R Emmons… - Frontiers in …, 2019 - frontiersin.org
Cardiovascular disease remains the leading cause of death worldwide. Myocardial ischemia
is a major contributor to cardiovascular morbidity and mortality. In the case of acute …

[PDF][PDF] Defining the metabolic signatures associated with human macrophage polarisation

A Povo-Retana, R Landauro-Vera… - Biochemical Society …, 2023 - portlandpress.com
Macrophages are essential components of the innate immune system that play both
homeostatic roles in healthy organs, and host defence functions against pathogens after …

N-phenethyl-5-phenylpicolinamide alleviates inflammation in acute lung injury by inhibiting HIF-1α/glycolysis/ASIC1a pathway

N Du, H Lin, A Zhang, C Cao, X Hu, J Zhang, L Wang… - Life Sciences, 2022 - Elsevier
Aims Acute lung injury (ALI) is triggered by an acute inflammatory response.
Lipopolysaccharide (LPS) is recognized as an important participant in the pathogenesis of …

[HTML][HTML] Dexmedetomidine inhibits LPS-induced proinflammatory responses via suppressing HIF1α-dependent glycolysis in macrophages

Q Meng, P Guo, Z Jiang, L Bo, J Bian - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Dexmedetomidine, a highly selective α2-adrenoceptor agonist, has been reported to exert
an anti-inflammatory effect in several animal models, but the mechanism remains unclear …

Graphene particles interfere with pro‐inflammatory polarization of human macrophages: functional and electrophysiological evidence

A Povo‐Retana, M Mojena, A Boscá… - Advanced …, 2021 - Wiley Online Library
The interaction of two types of fragmented graphene particles (30–160 nm) with human
macrophages is studied. Since macrophages have significant phagocytic activity, the …

[HTML][HTML] HIF1α-Induced Glycolysis in Macrophage Is Essential for the Protective Effect of Ouabain during Endotoxemia

C Shao, S Lin, S Liu, P Jin, W Lu, N Li… - … medicine and cellular …, 2019 - hindawi.com
Ouabain, a steroid binding to the Na+/K+-ATPase, has several pharmacological effects. In
addition to the recognized effects of blood pressure, there is more convincing evidence …