Mechanism of action of ribosomally synthesized and post-translationally modified peptides

C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

Mechanistic understanding of lanthipeptide biosynthetic enzymes

LM Repka, JR Chekan, SK Nair… - Chemical …, 2017 - ACS Publications
Lanthipeptides are ribosomally synthesized and post-translationally modified peptides
(RiPPs) that display a wide variety of biological activities, from antimicrobial to antiallodynic …

Guidelines for evaluating myocardial cell death

PK Mishra, A Adameova, JA Hill… - American Journal …, 2019 - journals.physiology.org
Cell death is a fundamental process in cardiac pathologies. Recent studies have revealed
multiple forms of cell death, and several of them have been demonstrated to underlie …

Metformin as a radiation modifier; implications to normal tissue protection and tumor sensitization

K Mortezaee, D Shabeeb, AE Musa… - Current clinical …, 2019 - ingentaconnect.com
Background: Nowadays, ionizing radiation is used for several applications in medicine,
industry, agriculture, and nuclear power generation. Besides the beneficial roles of ionizing …

[HTML][HTML] Promising biomarkers of radiation-induced lung injury: a review

X Liu, C Shao, J Fu - Biomedicines, 2021 - mdpi.com
Radiation-induced lung injury (RILI) is one of the main dose-limiting side effects in patients
with thoracic cancer during radiotherapy. No reliable predictors or accurate risk models are …

Lung tissue extracellular matrix‐derived hydrogels protect against radiation‐induced lung injury by suppressing epithelial–mesenchymal transition

J Zhou, P Wu, H Sun, H Zhou… - Journal of Cellular …, 2020 - Wiley Online Library
This study aimed to examine whether lung tissue extracellular matrix (ECM) hydrogels have
protective effects on radiation‐induced lung injury (RILI). The cytocompatibility and …

The time course of radiation-induced lung injury in a nonhuman primate model of partial-body irradiation with minimal bone marrow sparing: clinical and radiographic …

TJ MacVittie, AM Farese, GA Parker… - Health Physics, 2019 - journals.lww.com
The primary objectives of two companion manuscripts were to assess the natural history of
delayed radiation-induced lung injury in a nonhuman primate model of acute high-dose …

Phosphatidylethanolamine targeting for cell death imaging in early treatment response evaluation and disease diagnosis

F Elvas, S Stroobants, L Wyffels - Apoptosis, 2017 - Springer
Phosphatidylethanolamine (PE) is one of the most abundant phospholipids in mammalian
plasma membranes. In healthy cells, PE resides predominantly in the inner leaflet of the cell …

Development of biomarkers for radiation biodosimetry and medical countermeasures research: Current status, utility, and regulatory pathways

MM Satyamitra, AL DiCarlo, BA Hollingsworth… - 2022 - meridian.allenpress.com
Biomarkers are important indicators of biological processes in health or disease. For this
reason, they play a critical role in advanced development of radiation biodosimetry tools and …

A trans-agency workshop on the pathophysiology of radiation-induced lung injury

DR Cassatt, A Gorovets, B Karimi-Shah, R Roberts… - 2022 - meridian.allenpress.com
Research and development of medical countermeasures (MCMs) for radiation-induced lung
injury relies on the availability of animal models with well-characterized pathophysiology …