Click chemistry: a transformative technology in nuclear medicine

D Bauer, SM Sarrett, JS Lewis, BM Zeglis - Nature protocols, 2023 - nature.com
Abstract The 2022 Nobel Prize in Chemistry was awarded to Professors K. Barry Sharpless,
Morten Meldal and Carolyn Bertozzi for their pioneering roles in the advent of click …

Click chemistry and radiochemistry: the first 10 years

JP Meyer, P Adumeau, JS Lewis… - Bioconjugate …, 2016 - ACS Publications
The advent of click chemistry has had a profound influence on almost all branches of
chemical science. This is particularly true of radiochemistry and the synthesis of agents for …

[HTML][HTML] Somatostatin receptor PET ligands-the next generation for clinical practice

E Pauwels, F Cleeren, G Bormans… - American Journal of …, 2018 - ncbi.nlm.nih.gov
Somatostatin receptors (SSTRs) are variably expressed by a variety of malignancies. Using
radiolabeled somatostatin analogs (SSAs), the presence of SSTRs on tumor cells may be …

[HTML][HTML] The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules

SJ Archibald, L Allott - EJNMMI radiopharmacy and chemistry, 2021 - Springer
Abstract The aluminium-[18F] fluoride ([18F] AlF) radiolabelling method combines the
favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal …

Multiplexed imaging for diagnosis and therapy

K Heinzmann, LM Carter, JS Lewis… - Nature Biomedical …, 2017 - nature.com
Complex molecular and metabolic phenotypes depict cancers as a constellation of different
diseases with common themes. Precision imaging of such phenotypes requires flexible and …

[18F]AlF-NOTA-octreotide PET imaging: biodistribution, dosimetry and first comparison with [68Ga]Ga-DOTATATE in neuroendocrine tumour patients

E Pauwels, F Cleeren, T Tshibangu, M Koole… - European Journal of …, 2020 - Springer
Purpose The widespread use of gallium-68-labelled somatostatin analogue (SSA) PET, the
current standard for somatostatin receptor (SSTR) imaging, is limited by practical and …

Recent advances in bioorthogonal click chemistry for enhanced PET and SPECT radiochemistry

X Zhong, J Yan, X Ding, C Su, Y Xu… - Bioconjugate …, 2023 - ACS Publications
Due to their high reaction rate and reliable selectivity, bioorthogonal click reactions have
been extensively investigated in numerous research fields, such as nanotechnology, drug …

Somatostatin receptor PET/MR imaging of inflammation in patients with large vessel vasculitis and atherosclerosis

A Ćorović, C Wall, M Nus, D Gopalan, Y Huang… - Journal of the American …, 2023 - jacc.org
Background Assessing inflammatory disease activity in large vessel vasculitis (LVV) can be
challenging by conventional measures. Objectives We aimed to investigate somatostatin …

Clinical application of 18F-AlF-NOTA-octreotide PET/CT in combination with 18F-FDG PET/CT for imaging neuroendocrine neoplasms

T Long, N Yang, M Zhou, D Chen, Y Li, J Li… - Clinical nuclear …, 2019 - journals.lww.com
Objectives The study is to evaluate biodistribution, dosimetry, safety, and clinical usefulness
of 18 F-AlF-NOTA-octreotide (18 F-OC) PET/CT in combination with 18 F-FDG PET/CT for …

[HTML][HTML] Radiolabelled peptides for positron emission tomography and endoradiotherapy in oncology

C Rangger, R Haubner - Pharmaceuticals, 2020 - mdpi.com
This review deals with the development of peptide-based radiopharmaceuticals for the use
with positron emission tomography and peptide receptor radiotherapy. It discusses the pros …