[HTML][HTML] Radiopharmaceuticals for PET and SPECT imaging: a literature review over the last decade

G Crișan, NS Moldovean-Cioroianu… - International Journal of …, 2022 - mdpi.com
Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

[HTML][HTML] Targeting mitophagy in Parkinson's disease

EH Clark, AV de la Torre, T Hoshikawa… - Journal of Biological …, 2021 - ASBMB
The genetics and pathophysiology of Parkinson's disease (PD) strongly implicate
mitochondria in disease aetiology. Elegant studies over the last two decades have …

The role of neuroimaging in Parkinson's disease

NSR Bidesi, I Vang Andersen… - Journal of …, 2021 - Wiley Online Library
Parkinson's disease (PD) is a neurodegenerative disorder that affects millions of people
worldwide. Two hallmarks of PD are the accumulation of alpha‐synuclein and the loss of …

[HTML][HTML] Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease

S Miller, MMK Muqit - Neuroscience letters, 2019 - Elsevier
The discovery of rare familial monogenic forms of early-onset Parkinson's disease has led to
the identification of a mitochondrial quality control process as a key player in this disease …

[HTML][HTML] Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development

SP McCluskey, C Plisson, EA Rabiner… - European journal of …, 2020 - Springer
Purpose A limit on developing new treatments for a number of central nervous system (CNS)
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …

Reconceptualization of translocator protein as a biomarker of neuroinflammation in psychiatry

T Notter, JM Coughlin, A Sawa, U Meyer - Molecular psychiatry, 2018 - nature.com
A great deal of interest in psychiatric research is currently centered upon the pathogenic role
of inflammatory processes. Positron emission tomography (PET) using radiolabeled ligands …

In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease

T Terada, T Obi, T Bunai, T Matsudaira, E Yoshikawa… - Neurology, 2020 - AAN Enterprises
Objective In vivo glycolysis-related glucose metabolism and electron transport chain-related
mitochondrial activity may be different regionally in the brains of patients with Alzheimer …

[HTML][HTML] Neuroimaging methods to map in vivo changes of OXPHOS and oxidative stress in neurodegenerative disorders

J Prasuhn, L Kunert, N Brüggemann - International Journal of Molecular …, 2022 - mdpi.com
Mitochondrial dysfunction is a pathophysiological hallmark of most neurodegenerative
diseases. Several clinical trials targeting mitochondrial dysfunction have been performed …

[HTML][HTML] Translation imaging in Parkinson's disease: focus on neuroinflammation

S Belloli, M Morari, V Murtaj, S Valtorta… - Frontiers in aging …, 2020 - frontiersin.org
Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the
substantia nigra pars compacta (SNpc) and the appearance of α-synuclein insoluble …

Fractal dimension estimation for developing pathological brain detection system based on Minkowski-Bouligand method

YD Zhang, XQ Chen, TM Zhan, ZQ Jiao, Y Sun… - IEEE …, 2016 - ieeexplore.ieee.org
It is of enormous significance to detect abnormal brains automatically. This paper develops
an efficient pathological brain detection system based on the artificial intelligence method …