Nanodiagnostics as a field makes use of fundamental advances in nanobiotechnology to
diagnose, characterize and manage disease at the molecular scale. As these strategies …

Background: The development of radiopharmaceuticals containing 225Ac for targeted alpha
therapy is an active area of academic and commercial research worldwide. Objectives …

Purpose Fibroblast activation protein (FAP) is a pan-cancer target and now the state-of-the-
art to develop radiopharmaceuticals. FAP inhibitors have been of great success in …

Abstract Effective use of the ${}^{225}{\rm Ac} $ decay chain in targeted internal
radioimmunotherapy requires the retention of both ${}^{225}{\rm Ac} $ and progeny isotopes …

Background Targeted alpha therapy (TAT) offers advantages over current β-emitting
conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors …

Clinically used iodinated computer tomography (CT) contrast agents suffer from low
sensitivity, and the emerging lanthanide-chelates and CT imaging nanoagents raise great …

The aim of this work was to explore 132La as a PET imaging surrogate for 225Ac using a
DOTA-based, tumor-targeting alkylphosphocholine (NM600). Methods: 132La was …

A variant of 1, 4, 7, 10-tetraazacyclododecane (cyclen) bearing two semicarbazone pendant
groups has been prepared. The octadentate ligand forms complexes with Bi3+ and Pb2+. X …

Despite improvements in small animal PET instruments, many tracers cannot be imaged at
sufficiently high resolutions due to positron range, while multi-tracer PET is hampered by the …

Core–shell systems have attracted increasing interest among the research community in
recent years due to their unique properties and structural features, and the development of …