Over the last few years, cancer immunotherapy experienced tremendous developments and
it is nowadays considered a promising strategy against many types of cancer. However, the …

Simple Summary Hypoxia is a key feature of the tumor microenvironment involved in the
pathogenesis of pancreatic ductal adenocarcinoma (PDAC). In this review we will highlight …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxic niches that lead to
treatment resistance. Therefore, studies of tumor oxygenation and metabolic profiling should …

Simple Summary Patients diagnosed with pancreatic cancer have a poor prognosis at time
of diagnosis, with a 5-year survival rate of merely 10%. The only treatment with curative …

The concept of tumour hypoxia as a cause of radiation resistance has been prevalent for
over 100 years. During this time, our understanding of tumour hypoxia has matured with the …

Objectives V-domain immunoglobulin suppressor of T-cell activation (VISTA) is constitutively
expressed in hematopoietic lineage and is highly up-regulated in tumor infiltrated myeloid …

Previous reports have suggested that the hypoxic microenvironment provides a niche that
supports tumor stem cells, and that this might explain clinical observations linking hypoxia to …

Purpose Improvements in personalized therapy are made possible by the advances in
molecular biology that led to developments in molecular imaging, allowing highly specific in …

Hypoxia, the state of low oxygenation that often arises in solid tumours due to their high
metabolism and irregular vasculature, is a major contributor to the resistance of tumours to …

Nanoscale perfluorocarbon (PFC) droplets have enormous potential as clinical theranostic
agents. They are biocompatible and are currently used in vivo as contrast agents for a …