Because of the compartmentalization of disciplines that shaped the academic landscape of
biology and biomedical sciences in the past, physiological systems have long been studied …

Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum
of their possible activation states is not well understood. We derived co-regulated gene …

An aged circulatory environment can activate microglia, reduce neural precursor cell activity
and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate …

Background: Studies investigating the impact of a variety of inflammatory stimuli on the brain
and behavior have reported evidence that inflammation and release of inflammatory …

Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …

As extremely sensitive immune cells, microglia act as versatile watchdogs of the central
nervous system (CNS) that tightly control tissue homeostasis. Therefore, microglial activation …

The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …

Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …

The mitochondrial protein, translocator protein (TSPO), is a widely used biomarker of
neuroinflammation, but its non-selective cellular expression pattern implies roles beyond …