Tissue clearing to examine tumour complexity in three dimensions

J Almagro, HA Messal, M Zaw Thin… - Nature Reviews …, 2021 - nature.com
The visualization of whole organs and organisms through tissue clearing and fluorescence
volumetric imaging has revolutionized the way we look at biological samples. Its application …

[HTML][HTML] Tissue architecture in tumor initiation and progression

J Almagro, HA Messal, A Elosegui-Artola… - Trends in Cancer, 2022 - cell.com
The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment
of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic …

PASylation®: a versatile technology to extend drug delivery

U Binder, A Skerra - Current opinion in colloid & interface science, 2017 - Elsevier
PASylation® technology comprises the conjugation–via genetic fusion or chemical coupling–
of pharmacologically active compounds, such as proteins, peptides and low molecular …

Protein engineering strategies for improved pharmacokinetics

A Rondon, S Mahri, F Morales‐Yanez… - Advanced Functional …, 2021 - Wiley Online Library
Protein therapeutics have gained momentum in recent years and become a pillar in treating
many diseases and the only choice in several ailments. Protein therapeutics are highly …

Deep tissue imaging: a review from a preclinical cancer research perspective

A Feuchtinger, A Walch, M Dobosz - Histochemistry and cell biology, 2016 - Springer
This review delves into the rapidly evolving field of deep tissue imaging at cellular
resolution, reviewing popular tissue clearing and staining methods in combination with light …

Recombinant protein polymer-antibody conjugates for applications in nanotechnology and biomedicine

AG Goncalves, EJ Hartzell, MO Sullivan… - Advanced Drug Delivery …, 2022 - Elsevier
Currently, there are over 100 antibody-based therapeutics on the market for the treatment of
various diseases. The increasing importance of antibody treatment is further highlighted by …

Molar activity of Ga-68 labeled PSMA inhibitor conjugates determines PET imaging results

A Wurzer, J Pollmann, A Schmidt, D Reich… - Molecular …, 2018 - ACS Publications
Radiopharmaceuticals targeting the enzyme prostate-specific membrane antigen (PSMA;
synonyms: glutamate carboxypeptidase II, NAALADase; EC 3.4. 17.21) have recently …

Influence of size and charge of unstructured polypeptides on pharmacokinetics and biodistribution of targeted fusion proteins

F Brandl, H Merten, M Zimmermann, M Béhé… - Journal of controlled …, 2019 - Elsevier
Alternative non-IgG binding proteins developed for therapy are small in size and, thus, are
rapidly cleared from the circulation by renal filtration. To avoid repeated injection or …

3D imaging for driving cancer discovery

RL van Ineveld, EJ van Vliet, EJ Wehrens… - The EMBO …, 2022 - embopress.org
Our understanding of the cellular composition and architecture of cancer has primarily
advanced using 2D models and thin slice samples. This has granted spatial information on …

Dual‐nuclide radiopharmaceuticals for positron emission tomography based dosimetry in radiotherapy

A Wurzer, C Seidl, A Morgenstern… - … A European Journal, 2018 - Wiley Online Library
Improvement of the accuracy of dosimetry in radionuclide therapy has the potential to
increase patient safety and therapeutic outcomes. Although positron emission tomography …