Tissue clearing to examine tumour complexity in three dimensions
The visualization of whole organs and organisms through tissue clearing and fluorescence
volumetric imaging has revolutionized the way we look at biological samples. Its application …
volumetric imaging has revolutionized the way we look at biological samples. Its application …
[HTML][HTML] Tissue architecture in tumor initiation and progression
The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment
of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic …
of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic …
PASylation®: a versatile technology to extend drug delivery
U Binder, A Skerra - Current opinion in colloid & interface science, 2017 - Elsevier
PASylation® technology comprises the conjugation–via genetic fusion or chemical coupling–
of pharmacologically active compounds, such as proteins, peptides and low molecular …
of pharmacologically active compounds, such as proteins, peptides and low molecular …
Protein engineering strategies for improved pharmacokinetics
Protein therapeutics have gained momentum in recent years and become a pillar in treating
many diseases and the only choice in several ailments. Protein therapeutics are highly …
many diseases and the only choice in several ailments. Protein therapeutics are highly …
Deep tissue imaging: a review from a preclinical cancer research perspective
A Feuchtinger, A Walch, M Dobosz - Histochemistry and cell biology, 2016 - Springer
This review delves into the rapidly evolving field of deep tissue imaging at cellular
resolution, reviewing popular tissue clearing and staining methods in combination with light …
resolution, reviewing popular tissue clearing and staining methods in combination with light …
Recombinant protein polymer-antibody conjugates for applications in nanotechnology and biomedicine
AG Goncalves, EJ Hartzell, MO Sullivan… - Advanced Drug Delivery …, 2022 - Elsevier
Currently, there are over 100 antibody-based therapeutics on the market for the treatment of
various diseases. The increasing importance of antibody treatment is further highlighted by …
various diseases. The increasing importance of antibody treatment is further highlighted by …
Molar activity of Ga-68 labeled PSMA inhibitor conjugates determines PET imaging results
A Wurzer, J Pollmann, A Schmidt, D Reich… - Molecular …, 2018 - ACS Publications
Radiopharmaceuticals targeting the enzyme prostate-specific membrane antigen (PSMA;
synonyms: glutamate carboxypeptidase II, NAALADase; EC 3.4. 17.21) have recently …
synonyms: glutamate carboxypeptidase II, NAALADase; EC 3.4. 17.21) have recently …
Influence of size and charge of unstructured polypeptides on pharmacokinetics and biodistribution of targeted fusion proteins
F Brandl, H Merten, M Zimmermann, M Béhé… - Journal of controlled …, 2019 - Elsevier
Alternative non-IgG binding proteins developed for therapy are small in size and, thus, are
rapidly cleared from the circulation by renal filtration. To avoid repeated injection or …
rapidly cleared from the circulation by renal filtration. To avoid repeated injection or …
3D imaging for driving cancer discovery
RL van Ineveld, EJ van Vliet, EJ Wehrens… - The EMBO …, 2022 - embopress.org
Our understanding of the cellular composition and architecture of cancer has primarily
advanced using 2D models and thin slice samples. This has granted spatial information on …
advanced using 2D models and thin slice samples. This has granted spatial information on …
Dual‐nuclide radiopharmaceuticals for positron emission tomography based dosimetry in radiotherapy
A Wurzer, C Seidl, A Morgenstern… - … A European Journal, 2018 - Wiley Online Library
Improvement of the accuracy of dosimetry in radionuclide therapy has the potential to
increase patient safety and therapeutic outcomes. Although positron emission tomography …
increase patient safety and therapeutic outcomes. Although positron emission tomography …