[HTML][HTML] The mechanisms of action of metformin

G Rena, DG Hardie, ER Pearson - Diabetologia, 2017 - Springer
Metformin is a widely-used drug that results in clear benefits in relation to glucose
metabolism and diabetes-related complications. The mechanisms underlying these benefits …

Cellular and molecular mechanisms of metformin action

TE LaMoia, GI Shulman - Endocrine reviews, 2021 - academic.oup.com
Metformin is a first-line therapy for the treatment of type 2 diabetes, due to its robust glucose-
lowering effects, well-established safety profile, and relatively low cost. While metformin has …

[HTML][HTML] Metformin: Update on mechanisms of action and repurposing potential

M Foretz, B Guigas, B Viollet - Nature Reviews Endocrinology, 2023 - nature.com
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …

[HTML][HTML] Metformin: Is it a drug for all reasons and diseases?

CR Triggle, I Mohammed, K Bshesh, I Marei, K Ye… - Metabolism, 2022 - Elsevier
Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

M Foretz, B Guigas, B Viollet - Nature Reviews Endocrinology, 2019 - nature.com
Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …

[HTML][HTML] From pre-diabetes to diabetes: diagnosis, treatments and translational research

RMM Khan, ZJY Chua, JC Tan, Y Yang, Z Liao, Y Zhao - Medicina, 2019 - mdpi.com
Diabetes, a silent killer, is one of the most widely prevalent conditions of the present time.
According to the 2017 International Diabetes Federation (IDF) statistics, the global …

[HTML][HTML] Role of mitochondria in the mechanism (s) of action of metformin

G Vial, D Detaille, B Guigas - Frontiers in endocrinology, 2019 - frontiersin.org
Metformin is a drug from the biguanide family that is used for decades as the first-line
therapeutic choice for the treatment of type 2 diabetes. Despite its worldwide …

Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss

EA Day, RJ Ford, BK Smith… - Nature …, 2019 - nature.com
Metformin is the most commonly prescribed medication for type 2 diabetes, owing to its
glucose-lowering effects, which are mediated through the suppression of hepatic glucose …

Metformin and systemic metabolism

L He - Trends in Pharmacological Sciences, 2020 - cell.com
Metformin can improve patients' hyperglycemia through significant suppression of hepatic
glucose production. However, up to 300 times higher concentrations of metformin …

Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis

TE LaMoia, GM Butrico, HA Kalpage… - Proceedings of the …, 2022 - National Acad Sciences
Metformin exerts its plasma glucose-lowering therapeutic effect primarily through inhibition
of hepatic gluconeogenesis. However, the precise molecular mechanism by which …