Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

Abstract Introduction The Alzheimer's Association convened a multidisciplinary workgroup to
develop appropriate use criteria to guide the safe and optimal use of the lumbar puncture …

Purpose To provide an overview on positron emission tomography (PET) imaging of tau
pathology in Alzheimer's disease (AD) and other neurodegenerative disorders. Results …

Evidence supporting the hypothesis that reduced cerebrospinal fluid (CSF) clearance is
involved in the pathophysiology of Alzheimer disease (AD) comes primarily from rodent …

Purpose A limit on developing new treatments for a number of central nervous system (CNS)
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …

Amyloid peptides and proteins are associated with the pathologies of numerous diseases. In
the progression of a disease, amyloids exist in soluble and insoluble forms, which are the …

Abnormal accumulation of Tau protein is closely associated with neurodegeneration and
cognitive impairment and it is a biomarker of neurodegeneration in the dementia field …

Abnormal deposition of amyloid-β and hyperphosphorylated tau protein in the brain are the
pathologic hallmark of Alzheimer disease (AD). Noninvasive detection of the lesions is …

Alzheimer's disease and other neurodegenerative dementias belong to the family of
tauopathies. These diseases are characterized by the deposition of insoluble tau …

Abstract Background In sporadic Alzheimer's disease (AD), brain amyloid-beta (Aβ)
deposition is believed to be a consequence of impaired Aβ clearance, but this relationship is …