Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …

Microglia, as cellular mediators of neuroinflammation, are implicated in the pathogenesis of
a wide range of neurodegenerative diseases. Positron emission tomography (PET) imaging …

Purpose Imaging has become increasingly important across medical specialties for
diagnostic, monitoring, and investigative purposes in acute respiratory distress syndrome …

Tumor associated macrophages (TAM) are key players in the cancer microenvironment.
Molecular imaging modalities such as MRI and PET can be used to track and monitor TAM …

Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two interrelated
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …

Macrophages are key players in the pathogenesis of large-vessel vasculitis (LVV) and may
serve as a target for diagnostic imaging of LVV. The radiotracer, 18 F-FDG has proven to be …

Understanding the mechanisms underlying progression in multiple sclerosis (MS) is one of
the key elements contributing to the identification of appropriate therapeutic targets for this …

Alzheimer's disease (AD) is the most frequent cause of dementia worldwide. The etiology of
AD is partially explained by the deposition of β-amyloid in the brain. Despite extensive …

Giant cell arteritis (GCA) is a granulomatous large-vessel vasculitis that affects adults above
50 years of age. In GCA, circulating monocytes are recruited to the inflamed arteries. With …

Acute respiratory distress syndrome (ARDS) is a serious complication of severe systemic or
local pulmonary inflammation, such as caused by severe acute respiratory syndrome …