The development of methods to accurately quantify cell-surface receptors in living tissues
would have a seminal impact in oncology. For example, accurate measures of receptor …

Immune checkpoint blockade has emerged as a promising cancer treatment paradigm.
Unfortunately, there are still a large number of patients and malignancies that do not …

The complete removal of cancerous tissue is a central aim of surgical oncology, but is
difficult to achieve in certain cases, especially when the removal of surrounding normal …

Purpose: Prostate stem cell antigen (PSCA) is highly expressed in local prostate cancers
and prostate cancer bone metastases and its expression correlates with androgen receptor …

In vitro properties of antibody–drug conjugates (ADCs) such as binding, internalization, and
cytotoxicity are often well characterized before in vivo studies. Interpretation of in vivo …

Antibodies, and engineered antibody fragments, labeled with radioisotopes are being
developed as radiotracers for the detection and phenotyping of diseases such as cancer …

Immuno-positron emission tomography (immunoPET) enables imaging of specific targets
that play a role in targeted therapy and immunotherapy, such as antigens on cell …

Background Graphical methods of radiotracer kinetic modeling in PET are ideal for
parametric imaging and data quality assurance but can suffer from noise bias. This study …

Immune checkpoint inhibitors (ICIs) have transformed the treatment paradigms for multiple
cancers. However, ICI therapy often fails to generate measurable and sustained antitumor …

Optical tomography can yield anatomical and molecular information about biological tissue.
However, its spatial resolution is poor in thick samples owing to high scatter. Early photon …