Complex molecular and metabolic phenotypes depict cancers as a constellation of different
diseases with common themes. Precision imaging of such phenotypes requires flexible and …

Despite numerous clinical trials and pre-clinical developments, the treatment of glioblastoma
(GB) remains a challenge. The current survival rate of GB averages one year, even with an …

Metabolomic profiling offers a powerful methodology for understanding the perturbations of
biochemical systems occurring during a disease process. During neoplastic transformation …

Cancer cells do reprogram their energy metabolism to enable several functions, such as
generation of biomass including membrane biosynthesis, and overcoming bioenergetic and …

Abstract Background Somatostatin receptor-2 (SSTR2) is expressed on cell surface of
neuroendocrine neoplasias; its presence is exploited for the delivery of peptide receptor …

Background Epidemiological studies suggest that metformin may reduce the incidence of
cancer in patients with diabetes and multiple late phase clinical trials assessing the potential …

As our knowledge of cancer metabolism has increased, it has become apparent that cancer
metabolic processes are extremely heterogeneous. The reasons behind this heterogeneity …

In humans, C–X–C chemokine receptor type 4 (CXCR4) is a protein that is encoded by the
CXCR4 gene and binds the ligand CXCL12 (also known as SDF-1). The CXCR4–CXCL12 …

Positron emission tomography (PET) has proven to be an invaluable tool in the staging and
management of disease in oncology; however,[18F] fluorodeoxyglucose ([18F] FDG) …

Positron emission tomography (PET) is an extraordinarily sensitive clinical imaging modality
for interrogating tumor metabolism. Radiolabeled PET substrates can be traced at …