Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms
F Bao, L Zhou, R Zhou, Q Huang, J Chen, S Zeng… - Science …, 2022 - science.org
Mitochondrial quality control plays an important role in maintaining mitochondrial
homeostasis and function. Disruption of mitochondrial quality control degrades brain …
homeostasis and function. Disruption of mitochondrial quality control degrades brain …
18F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with 18F-FDG and 11C-Methionine PET
T Watabe, H Ikeda, S Nagamori… - European journal of …, 2017 - Springer
Purpose The purpose of this study was to evaluate the usefulness of L-4-borono-2-18 F-
fluoro-phenylalanine (18 F-FBPA) as a tumor-specific probe, in comparison to 18 F-FDG and …
fluoro-phenylalanine (18 F-FBPA) as a tumor-specific probe, in comparison to 18 F-FDG and …
[HTML][HTML] Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized 13C-MRSI
Modern oncology aims at patient-specific therapy approaches, which triggered the
development of biomedical imaging techniques to synergistically address tumor biology at …
development of biomedical imaging techniques to synergistically address tumor biology at …
[HTML][HTML] Imaging technologies for cerebral pharmacokinetic studies: progress and perspectives
W Ban, Y You, Z Yang - Biomedicines, 2022 - mdpi.com
Pharmacokinetic assessment of drug disposition processes in vivo is critical in predicting
pharmacodynamics and toxicology to reduce the risk of inappropriate drug development …
pharmacodynamics and toxicology to reduce the risk of inappropriate drug development …
[HTML][HTML] In vivo magnetic particle imaging: Angiography of inferior vena cava and aorta in rats using newly developed multicore particles
A Mohtashamdolatshahi, H Kratz, O Kosch… - Scientific reports, 2020 - nature.com
Abstract Magnetic Particle Imaging (MPI) is a new imaging modality, which maps the
distribution of magnetic nanoparticles (MNP) in 3D with high temporal resolution. It thus may …
distribution of magnetic nanoparticles (MNP) in 3D with high temporal resolution. It thus may …
Modulating macrophage clearance of nanoparticles: comparison of small-molecule and biologic drugs as pharmacokinetic modifiers of soft nanomaterials
Nanomedicines show benefits in overcoming the limitations of conventional drug delivery
systems by reducing side effects, toxicity, and exhibiting enhanced pharmacokinetic (PK) …
systems by reducing side effects, toxicity, and exhibiting enhanced pharmacokinetic (PK) …
H2RSPET: a 0.5 mm resolution high-sensitivity small-animal PET scanner, a simulation study
With the goal of developing a total-body small-animal PET system with a high spatial
resolution of∼ 0.5 mm and a high sensitivity> 10% for mouse/rat studies, we simulated four …
resolution of∼ 0.5 mm and a high sensitivity> 10% for mouse/rat studies, we simulated four …
Performance evaluation of SimPET-X, a PET insert for simultaneous mouse total-body PET/MR imaging
Purpose In this study, a small animal PET insert (SimPET-X, Brightonix Imaging Inc.) for
simultaneous PET/MR imaging studies is presented. This insert covers an 11-cm-long axial …
simultaneous PET/MR imaging studies is presented. This insert covers an 11-cm-long axial …
Anesthesia and Preconditioning Induced Changes in Mouse Brain [18F] FDG Uptake and Kinetics
P Bascuñana, JT Thackeray, M Bankstahl… - Molecular imaging and …, 2019 - Springer
Abstract Purpose 2-Deoxy-2-[18 F] fluoro-D-glucose ([18 F] FDG) has been widely used for
imaging brain metabolism. Tracer injection in anesthetized animals is a prerequisite for …
imaging brain metabolism. Tracer injection in anesthetized animals is a prerequisite for …
[HTML][HTML] Conditional ablation of myeloid TNF increases lesion volume after experimental stroke in mice, possibly via altered ERK1/2 signaling
BH Clausen, M Degn, M Sivasaravanaparan… - Scientific reports, 2016 - nature.com
Microglia are activated following cerebral ischemia and increase their production of the
neuro-and immunomodulatory cytokine tumor necrosis factor (TNF). To address the function …
neuro-and immunomodulatory cytokine tumor necrosis factor (TNF). To address the function …