Radioactive transition metals for imaging and therapy

E Boros, AB Packard - Chemical reviews, 2018 - ACS Publications
Nuclear medicine is composed of two complementary areas, imaging and therapy. Positron
emission tomography (PET) and single-photon imaging, including single-photon emission …

[HTML][HTML] Radiometals in Imaging and Therapy: Highlighting Two Decades of Research

S Sharma, MK Pandey - Pharmaceuticals, 2023 - mdpi.com
The present article highlights the important progress made in the last two decades in the
fields of molecular imaging and radionuclide therapy. Advancements in radiometal-based …

[HTML][HTML] Production of radiometals in liquid targets

SJC do Carmo, PJH Scott, F Alves - EJNMMI Radiopharmacy and …, 2020 - Springer
Over the last several years, the use of radiometals has gained increasing relevance in
supporting the continuous development of new, complementary and more specific biological …

[HTML][HTML] Cyclotron production of PET radiometals in liquid targets: aspects and prospects

MK Pandey, TR DeGrado - Current radiopharmaceuticals, 2021 - ncbi.nlm.nih.gov
The present review describes the methodological aspects and prospects of the production of
Positron Emission Tomography (PET) radiometals in a liquid target using low-medium …

Insights into trace metal metabolism in health and disease from PET:“PET metallomics”

JJ Bartnicka, PJ Blower - Journal of Nuclear Medicine, 2018 - Soc Nuclear Med
Essential trace metals such as copper, zinc, iron, and manganese perform critical functions
in cellular and physiologic processes including catalytic, regulatory, and signaling roles …

Production of Y-86 and other radiometals for research purposes using a solution target system

E Oehlke, C Hoehr, X Hou, V Hanemaayer… - Nuclear medicine and …, 2015 - Elsevier
Introduction Diagnostic radiometals are typically obtained from cyclotrons by irradiating solid
targets or from radioisotope generators. These methods have the advantage of high …

[HTML][HTML] Recovery of Gallium-68 and Zinc from HNO3-Based Solution by Liquid–Liquid Extraction with Arylamino Phosphonates

F Zhuravlev, A Gulzar, L Falborg - Molecules, 2022 - mdpi.com
The cyclotron production of gallium-68 via the 68Zn (p, n) 68Ga nuclear reaction in liquid
targets is gaining significant traction in clinics. This work describes (1) the synthesis of new …

Expanding PET-applications in life sciences with positron-emitters beyond fluorine-18

HH Coenen, J Ermert - Nuclear medicine and biology, 2021 - Elsevier
Abstract Positron-emission-tomography (PET) has become an indispensable diagnostic tool
in modern nuclear medicine. Its outstanding molecular imaging features allow repetitive …

[HTML][HTML] Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission …

G Firth, E Georgiadou, A Griffiths, M Amrahli… - Frontiers in …, 2023 - frontiersin.org
Introduction Common variants in the SLC30A8 gene, encoding the secretory granule zinc
transporter ZnT8 (expressed largely in pancreatic islet alpha and beta cells), are associated …

Imaging zinc trafficking in vivo by positron emission tomography with zinc-62

G Firth, Z Yu, JJ Bartnicka, D Parker, J Kim… - Metallomics, 2022 - academic.oup.com
Non-invasive imaging techniques to dynamically map whole-body trafficking of essential
metals in vivo in health and diseases are needed. Despite 62Zn having appropriate physical …